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Behavioral Pharmacology of Hallucinogens

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Handbook of Substance Abuse

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Abstract

All classic hallucinogens produce unique subjective effects on the basic functions of the human mind: perception, affect, cognition, volition, and interoception. Despite these usually profound effects, the individual retains contact with reality and memory during the altered state. Subtle differences are ascribed to particular compounds, although their subjective effects are more alike than different. These subjective effects account for the use of hallucinogens in established rituals of some cultures as well as the use and abuse of them in contemporary Western culture. Hallucinogens differ from other drugs of abuse in that tolerance develops rapidly and there is no physical dependence. The unique and profound effect on cognitive processes makes the hallucinogens valuable in neuroscientific research, and the discovery of LSD’s psychotropic effects, as much as the contemporaneous discovery of chlorpromazine, mark the beginning of modern biological psychiatry (Strassman, 1995).

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References

  • Abraham, H. D., & Aldridge, A. M. (1993). Adverse consequences of lysergic acid diethylamide. Addiction, 88, 1327–1334.

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders ( 4th ed. ). Washington, DC: Author.

    Google Scholar 

  • Beck, J. E., & Gordon, D. V. (1982). Psilocybin mushrooms. Pharmaceutical Chemistry Newsletter, 4, 1–4.

    CAS  Google Scholar 

  • Brady, K. T., Casto, S., Lydiard, R. B., & Malcolm, R. (1991). Substance abuse in an inpatient psychiatric example. American Journal of Drug and Alcohol Abuse, 17, 389–397.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, R. J. (1989). Psychiatric dictionary ( 6th ed. ). New York: Oxford University Press.

    Google Scholar 

  • Cappendijk, S. L., & Dzoljic, M. R. (1993). Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology, 241, 261–265.

    Article  PubMed  CAS  Google Scholar 

  • Chandler, A. L., & Hartman, M. A. (1960). Lysergic acid diethylamide (LSD-25) as a facilitating agent in psychotherapy. Archives of General Psychiatry, 2, 286–299.

    Article  Google Scholar 

  • Controlled Substances Act, Public L No. 91–153, 21 USC 801 et. seq (1970).

    Google Scholar 

  • DeKorne, J. (1994). Psychedelic shamanism. Port Townsend, WA: Loompanics.

    Google Scholar 

  • Dobkin de Rios, M. (1984). Hallucinogens: Cross-cultural perspectives. Albuquerque: University of New Mexico Press.

    Google Scholar 

  • Dulit, R. A., Fryer, M. R., Haas, G. L., Sullivan, T., & Francis, A. J. (1990). Substance use in borderline personality disorder. American Journal of Psychiatry, 147, 1002–1007.

    PubMed  CAS  Google Scholar 

  • Freedman, D. X. (1968). On the use and abuse of LSD. Archives of General Psychiatry, 18, 330–347.

    Article  PubMed  CAS  Google Scholar 

  • Gillin, J. C., Kaplan, J., Stillman, R., & Wyatt, R. J. (1976). The psychedelic model of schizophrenia: The case of n,n-dimethyltryptamine. American Journal of Psychiatry, 133, 203–208.

    PubMed  CAS  Google Scholar 

  • Glennon, R. A. (1991). Discriminative stimulus properties of hallucinogens and related designer drugs. In R. A. Glennon, T. Jarbe, & J. Frankenheim (Eds.), Drug discrimination: Applications to drug research (NIDA Research Monograph No. 116, pp. 25–44 ). Washington, DC: U.S. Government Printing Office.

    Google Scholar 

  • Glennon, R. A. (1994). Classical hallucinogens: An introductory overview. In G. C. Lin & R. A. Glennon (Eds.), Hallucinogens: An update (NIDA Monograph Series No. 146, pp. 4–32 ). Washington, DC: U.S. Department of Health and Human Services.

    Google Scholar 

  • Glick, S. D., Rossman, K., Wang, S., Dong, N., & Keller, R. W, Jr. (1993). Local effects of ibogaine on extra-cellular levels of dopamine and its metabolites in nucleus accumbens and striatum: Interactions with D-amphetamine. Brain Research, 628, 201–208.

    Article  PubMed  CAS  Google Scholar 

  • Glick, S. D., Kuehne, M. E., Raucci, J., Wilson, T. E., Larson, D., & Keller, R. W., Jr. (1994). Effects of iboga alkaloids on morphine and cocaine self-administration in rats: Relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research, 657, 14–22.

    Article  PubMed  CAS  Google Scholar 

  • Gold, M. S. (1994). The epidemiology, attitudes, and pharmacology of LSD use in the 1990s. Psychiatric Annals, 24, 124–126.

    Google Scholar 

  • Grigsby, J. P. (1987). The use of imagery in the treatment of posttraumatic stress disorder. Journal of Nervous and Mental Disorders, 175, 55–59.

    Article  CAS  Google Scholar 

  • Grinspoon, L., & Balaker J. (1979). Psychedelic drugs reconsidered. New York: Basic Books.

    Google Scholar 

  • Grob, C., & Dobkin de Rios, M. (1992). Adolescent drug use in cross-cultural perspective. Journal of Drug Issues, 22, 122–138.

    Google Scholar 

  • Grof, S. (1980). LSD Psychotherapy. Alameda, CA: Hunter House.

    Google Scholar 

  • Grof, S., Goodman, L. E., Richards, W. A., & Kurland, A. A. (1973). LSD-assisted psychotherapy in patients with terminal cancer. International Pharmacopsychiatry, 8, 129–144.

    CAS  Google Scholar 

  • Harrison, P. A., Hoffman, N. G., & Edwall, G. E. (1989). Differential drug use patterns among sexually abused adolescent girls in treatment for chemical dependency. International Journal of the Addictions, 24, 499–514.

    PubMed  CAS  Google Scholar 

  • Hoffman, L. (1980). LSD, my problem child. New York: McGraw-Hill.

    Google Scholar 

  • Hollister, L. E., Degan, R. O., & Schultz, S. D. (1962). An experimental approach to facilitation of psychotherapy by psychotomimetic drugs. Journal of Mental Sciences, 108, 99–100.

    CAS  Google Scholar 

  • Hollister, L. E., Shelton, J., & Krieger, G. (1969). A controlled comparison of lysergic acid diethylamide (LSD) and dextroamphetamine in alcoholics. American Journal of Psychiatry, 125, 1352–1357.

    PubMed  CAS  Google Scholar 

  • Huxley, A. (1954). Doors of perception. New York: Harper & Row.

    Google Scholar 

  • Isbell, H., Belleville, R. E., Fraser, H. F., Wikler, A., & Logan, C. R. (1956). Studies on lysergic acid diethylamide: I. Effects in former morphine addicts and development of tolerance during chronic intoxication. Archives of General Psychiatry 76, 468–478.

    Google Scholar 

  • James, W. (1902). The varieties of religious experience. New York: Modern Library.

    Book  Google Scholar 

  • Kast, E. C., & Collins, V. J. (1964). Study of lysergic acid diethylamide as an analgesic agent. Anesthesia and Analgesia, 43, 285–291.

    Article  PubMed  CAS  Google Scholar 

  • Kern, M. E, Kenkel, M. B., Templer, D. I., & Newell, T. G. (1986). Drug preference as a function of arousal and stimulus screening. International Journal of the Addictions, 21, 255–265.

    PubMed  CAS  Google Scholar 

  • Kerr, B., Shaffer, J., Chambers, C., & Hallowell, K. (1991). Substance abuse of creatively talented adults. Journal of Creative Behavior, 25, 145–153.

    Article  Google Scholar 

  • Linton, H. B., & Langs, R. J. (1962). Subjective reactions to lysergic acid diethylamide (LSD-25). Archives of General Psychiatry, 6, 36–52.

    Google Scholar 

  • Mabry, E. A., & Khavari, K. A. (1986). Attitude and personality correlates of hallucinogenic drug use. International Journal of the Addictions, 21, 691–699.

    PubMed  CAS  Google Scholar 

  • Matefy, R., & Krawl, R. (1974). An initial investigation of the psychedelic drug flashback phenomena. Journal of Consulting and Clinical Psychology, 43, 434.

    Article  Google Scholar 

  • Milhorn, H. T. (1990). Chemical dependence: Diagnosis, treatment and prevention. New York: Springer-Verlag.

    Book  Google Scholar 

  • Millman, R. B., & Beeder, A. B. (1994). The new psychedelic culture: LSD, ecstasy, “rave” parties and the Grateful Dead. Psychiatric Annals, 24, 148–150.

    Google Scholar 

  • National Institute on Drug Abuse. (1986). National Household Survey on Drug Abuse: Populations estimates 1985. Rockville, MD: U.S. Department of Health and Human Services.

    Google Scholar 

  • National Institute on Drug Abuse. (1989). National Household Survey on Drug Abuse: Populations estimates 1988. Rockville, MD: U.S. Department of Health and Human Services.

    Google Scholar 

  • National Institute on Drug Abuse. (1991). National Household Survey on Drug Abuse: Populations estimates 1990. Rockville, MD: U.S. Department of Health and Human Services.

    Google Scholar 

  • O’Brien, R., & Cohen, S. (1984). The encyclopedia of drug abuse. New York: Facts on File.

    Google Scholar 

  • Pahnke, W. N., Kurland, A. A., Unger, S., Savage, C., & Grof, S. (1970). The experimental use of psychedelic (LSD) psychotherapy. Journal of the American Medical Association, 212, 1856–1863.

    Article  PubMed  CAS  Google Scholar 

  • Patterson, E. W., Myers, G., & Gallant, D. M. (1988). Patterns of substance use on a college campus: A 14-year comparison study. American Journal of Drug and Alcohol Abuse, 14, 237–246.

    Article  PubMed  CAS  Google Scholar 

  • Pearl, S. M., Herrick-Davis, K., Teitler, M., & Glick, S. D. (1995). Radioligand-binding study of noribogaine, a likely metabolite of ibogaine. Brain Research, 675, 342–344.

    Article  PubMed  CAS  Google Scholar 

  • Pope, H. G., lonescu-Pioggia, M., Aizley, H. G., & Varma, D. K. (1990). Drug use and life among college undergraduates in 1989: A comparison with 1969 and 1978. American Journal of Psychiatry, 147, 998–1001.

    Google Scholar 

  • Pride Survey, 1991–92. (1992). National summary, United States, grades 6–12. Bowling Green KY: Pride.

    Google Scholar 

  • Pride Survey, 1992–1993. (1993). National summary, United States, grades 6–12. Bowling Green, KY: Pride.

    Google Scholar 

  • Richards, R. A. (1978). Mystical and archetypal experiences of terminal patients in DPT-assisted psychotherapy. Journal of Religion and Health, 17, 117–126.

    Article  Google Scholar 

  • Richards, W. A., Rhead, J. C., DiLeo, F. B., Yensen, R., & Kurland, A. A. (1977). The peak experience variable in DPT-assisted psychotherapy with cancer patients. Journal of Psychedelic Drugs, 9, 1–10.

    Article  Google Scholar 

  • Russell, J. M., Newman, S. C., & Bland, R. C. (1994). Drug abuse and dependence. Acta Psychiatry Scandinavia, 376, 54–62.

    Article  CAS  Google Scholar 

  • Savage, C. (1952). Lysergic acid diethylamide (LSD-25). A clinical-psychological study. American Journal of Psychiatry, 108, 896–900.

    PubMed  CAS  Google Scholar 

  • Schick, J., & Smith, D. (1970). Analysis of the LSD flash- back. Journal of Psychedelic Drugs, 3, 13–19.

    Article  Google Scholar 

  • Sershen, H., Hashim, A., & Lajtha, A. (1994). Ibogainereduces preference for cocaine consumption in C57BL/6BY mice. Pharmacology, Biochemistry and Behavior, 47, 13–19.

    Article  CAS  Google Scholar 

  • Shagass, C., & Bittle, R. (1967). Therapeutic effects of LSD: A follow-up study. Journal of Nervous and Mental Disorders, 144, 471–478.

    Article  CAS  Google Scholar 

  • Sheppard, S. G. (1994). A preliminary investigation of ibogaine: Case reports and recommendations for further study. Journal of Substance Abuse Treatment, 11, 379–385.

    Article  PubMed  CAS  Google Scholar 

  • Strassman, R. J. (1984). Adverse reactions to psychedelic drugs: A review of the literature. Journal of Nervous and Mental Disease, 172, 577–595.

    Article  PubMed  CAS  Google Scholar 

  • Strassman, R. J. (1991). Human hallucinogenic drug research in the United States: A present-day case history and review of the process. Journal of Psychoactive Drugs, 23, 29–38.

    Article  PubMed  CAS  Google Scholar 

  • Strassman, R. J. (1994). Human hallucinogenic drug research: Regulatory, clinical, and scientific issues. In G. C. Lin & R. A. Glennon (Eds.), Hallucinogens: An update (NIDA Monograph Series No. 146, pp. 92–123 ). Washington, DC: U.S. Department of Health and Human Services.

    Google Scholar 

  • Strassman, R. J. (1995). Hallucinogenic drugs in psychiatric research and treatment: Perspectives and prospects. Journal of Nervous and Mental Disease, 183, 127–138.

    Article  PubMed  CAS  Google Scholar 

  • Strassman, R. J., & Qualls, C. R. (1994). Dose-response study of n,n-dimethyltryptamine in humans: I. Neuroendocrine, autonomic, and cardiovascular effects. Archives of General Psychiatry, 51, 85–97.

    Article  PubMed  CAS  Google Scholar 

  • Strassman, R. J., Qualls, C. R., Uhlenhuth, E. H., & Kellner, R. (1994). Dose-response study of n,n-dimethyltryptamine in humans: II. Subjective effects and preliminary results of a new rating scale. Archives of General Psychiatry 51, 98–108.

    Article  PubMed  CAS  Google Scholar 

  • Szara, S. (1994). Are hallucinogenics psychoheuristic? In G. C. Lin & R. A. Glennon (Eds.), Hallucinogens: An update (NIDA Monograph Series No. 146, pp. 33–51 ). Washington, DC: U.S. Department of Health and Human Services.

    Google Scholar 

  • Wesson, D., & Smith, D. (1976). An analysis of psychedelic drug flashbacks. American Journal of Drug and Alcohol Abuse, 3, 425–438.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, The University of New Mexico, Albuquerque, New Mexico, 87131, USA

    Nancy K. Morrison

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  1. Nancy K. Morrison
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Editors and Affiliations

  1. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Ralph E. Tarter  & Peggy J. Ott  & 

  2. Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania, USA

    Robert T. Ammerman

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Morrison, N.K. (1998). Behavioral Pharmacology of Hallucinogens. In: Tarter, R.E., Ammerman, R.T., Ott, P.J. (eds) Handbook of Substance Abuse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2913-9_15

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  • DOI: https://doi.org/10.1007/978-1-4757-2913-9_15

  • Publisher Name: Springer, Boston, MA

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