Nitric Oxide Regulation of Membrane and Lipoprotein Oxidation in the Vasculature

A Radical Hypothesis
  • Bruce A. Freeman
  • Jason Eiserich
  • Valerie O’Donnell
Part of the NATO ASI Series book series (NSSA, volume 296)


Nitric oxide (·NO, nitrogen monoxide) exerts potent actions in the regulation of cell function and tissue viability that extend far beyond the recognized ability of ·NO to mediate signal transduction via activation of guanylate cyclase. Chemical reactions, cell culture systems, animal models and clinical studies have all revealed an ability of ·NO to modulate oxygen radical reactions and pathologic processes associated with inflammation. The focus of this article is to reveal the reactions of ·NO with reactive oxygen species and lipid radicals (LO· and LOO·) formed during membrane and lipoprotein oxidation. The products of these reactions, LONO/LNO2 and LOONO/LONO2 adducts, are potentially reactive and can serve as mediators of inflammation and tissue injury. Because of the high reactivity of ·NO with lipophilic radicals and the interactions that ·NO can have with lipophilic antioxidants, the reactions of ·NO with membrane and lipoprotein oxidant defense mechanisms will be explored as well.


Nitric Oxide NADPH Oxidase Xanthine Oxidase Guanylate Cyclase Lipoprotein Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Bruce A. Freeman
    • 1
    • 2
  • Jason Eiserich
    • 1
  • Valerie O’Donnell
    • 1
  1. 1.Departments of AnesthesiologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Biochemistry and Molecular GeneticsUniversity of Alabama at BirminghamBirminghamUSA

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