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Clastogenic Factors as Biomarkers of Oxidative Stress

Their Usefulness for Evaluation of the Efficacy of Antioxidant Treatments

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Book cover Free Radicals, Oxidative Stress, and Antioxidants

Part of the book series: NATO ASI Series ((NSSA,volume 296))

Abstract

Clastogenic factors (CF) have been recognized since the early seventieth as an indirect effect of ionizing radiation (Goh and Sumner, 1968; Hollowell and Littlefield, 1968). Because of their persistence in the blood of irradiated persons many years after exposure, they have been considered as risk factors for late effects of radiation, such as cancer and leukemia (Faguet, 1984). Previous work of our laboratory has shown that CF are not specific for irradiated subjects, but found in a variety of other pathological conditions, where they are biomarkers of oxidative stress. Their formation and their clastogenic action are related to increased superoxide production, since both are regularly inhibited by superoxide dismutase (SOD) (Emerit, 1994). They are not single factors, as thought by the first observers, but mixtures of chromosome-damaging pro-oxidant substances. Nevertheless the term “clastogenic factor” has been conserved.

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Authors and Affiliations

  1. Free Radical Research Group Institut biomédical des Cordeliers, University Paris VI, France

    Ingrid Emerit

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  1. Ingrid Emerit
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  1. Akdeniz University, Antalya, Turkey

    Tomris Özben

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Emerit, I. (1998). Clastogenic Factors as Biomarkers of Oxidative Stress. In: Özben, T. (eds) Free Radicals, Oxidative Stress, and Antioxidants. NATO ASI Series, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2907-8_32

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  • DOI: https://doi.org/10.1007/978-1-4757-2907-8_32

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