Oxidative Damage and Reperfusion Syndrome in Human Liver Transplantation

  • Fiorella Biasi
  • Juan Cutrin
  • Elena Chiarpotto
  • Mauro Salizzoni
  • Alessandro Franchello
  • Fausto Zamboni
  • Elisabetta Cerutti
  • Roberto Pagni
  • Giacomo Lanfranco
  • Isabella Chiappino
  • Giuseppe Poli
Chapter
Part of the NATO ASI Series book series (NSSA, volume 296)

Abstract

In the transplanted organ, early after reperfusion, a consistent while usually transient tissue damage is detectable which could interfere with appropriate recovery and function. In the case of transplanted human liver, a certain degree of cytolysis as well as post-hepatic cholestasis have actually been monitored early after surgery (Ericzon et al., 1990; Biasi et al., 1995). Then, studies addressed to elucidate the mechanisms underlying post-transplantation liver injury are necessary. The inflammatory process which always follows a cytolytic event generates a variety of molecules actually able to modulate not only cellular function but also its genetic program. Hence, extent and duration of flogistic reactions should be controlled for not being overwhelming tissue and organ homeostasis.

Keywords

Warm Ischemia Bile Canaliculus Plasma Lipid Peroxide Antioxidant Mixture Organ Homeostasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Fiorella Biasi
    • 1
  • Juan Cutrin
    • 2
  • Elena Chiarpotto
    • 2
  • Mauro Salizzoni
    • 3
  • Alessandro Franchello
    • 3
  • Fausto Zamboni
    • 3
  • Elisabetta Cerutti
    • 3
  • Roberto Pagni
    • 4
  • Giacomo Lanfranco
    • 4
  • Isabella Chiappino
    • 4
  • Giuseppe Poli
    • 2
  1. 1.CNR Centre of Immunogenetics and Experimental OncologyTorinoItaly
  2. 2.Department of Experimental Medicine and OncologyUniversity of TorinoItaly
  3. 3.Liver Transplantation CentreAzienda Ospedaliera S. Giovanni BattistaMolinette, TorinoItaly
  4. 4.Baldi e Riberi LaboratoryAzienda Ospedaliera S. Giovanni BattistaMolinette, TorinoItaly

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