The Role of Free Radical Mediation of Protein Oxidation in Aging and Disease

  • Earl R. Stadtman
Part of the NATO ASI Series book series (NSSA, volume 296)


A role of protein oxidation in aging is indicated by the following observations: The cellular level of oxidized protein increases with animal age. Age-related changes in enzyme activities can be mimicked by treatment of enzymes from young animals with reactive oxygen species (ROS) in vitro. Exposure of animals to conditions of oxidative stress leads to an increase in the intracellular level of oxidized protein. Factors that increase the life span of animals lead also to a decrease in the level of oxidized protein and vice versa. Many age-related diseases are associated with elevated levels of oxidized proteins. Some age-related changes in enzyme activities and cognitive functions can be reversed by exposing old animals to free radical spin traps. The age-related increase in oxidized proteins is a complex function of the balance between a multiplicity of prooxidants, antioxidants, and the activities of proteases that selectively degrade the oxidized forms of proteins.


Glutamine Synthetase Protein Carbonyl Protein Oxidation Oxidative Modification Carbonyl Content 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Earl R. Stadtman
    • 1
  1. 1.National Heart, Lung, and Blood Institute National Institutes of HealthLaboratory of BiochemistryBethesdaUSA

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