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Reactive Oxygen Species (ROS) and Alteration of F0F1-ATP Synthase in Aging and Liver Regeneration

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Free Radicals, Oxidative Stress, and Antioxidants

Part of the book series: NATO ASI Series ((NSSA,volume 296))

Abstract

The contribution of oxidative phosphorylation to cellular energy demand changes in the life span, being low in foetal tissues and increasing progressively after the birth until 80% and more of cellular ATP is provided by mitochondrial oxidative phosphorylation in the tissues from adult animals. Aging is characterized by a progressive decline of the oxidative phosphorylation process associated to alterations of respiratory complexes and F0F1—ATP synthase. The age dependent changes are tissue specific being more pronounced in the heart (a well differentiated tissue) than in liver. Damage of F0F1—ATP synthase has been also observed in the early phase of liver regeneration characterized by retrodifferentation of hepatocytes which change from oxidative to fermentative metabolism. In both cases, aging and liver regeneration, the reactive oxygen species are apparently involved in the damage of mitochondrial F0F1—ATP synthase.

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Authors and Affiliations

  1. Institute of Medical Biochemistry, Chemistry University of Bari, Italy

    Ferruccio Guerrieri, Giovanna Pellecchia & Prof. Sergio Papa

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  1. Ferruccio Guerrieri
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  2. Giovanna Pellecchia
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  3. Prof. Sergio Papa
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Correspondence to Sergio Papa .

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Editors and Affiliations

  1. Akdeniz University, Antalya, Turkey

    Tomris Özben

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© 1998 Springer Science+Business Media New York

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Guerrieri, F., Pellecchia, G., Papa, S. (1998). Reactive Oxygen Species (ROS) and Alteration of F0F1-ATP Synthase in Aging and Liver Regeneration. In: Özben, T. (eds) Free Radicals, Oxidative Stress, and Antioxidants. NATO ASI Series, vol 296. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2907-8_11

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  • DOI: https://doi.org/10.1007/978-1-4757-2907-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3292-1

  • Online ISBN: 978-1-4757-2907-8

  • eBook Packages: Springer Book Archive

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