Are Free Radicals Involved in the Expression of Adhesion Molecules?
It is beyond doubt that the adhesion of leukocytes to the endothelial lining of the vascular wall plays a key role in various biological processes, including inflammation and thrombosis. This phenomenon is the result of a complex interplay among blood flow, cell adhesion and molecular vascular biology factors. Normally, the circulating granulocytes and monocytes in peripheral blood are distributed over a circulating pool and a marginating pool. The marginating pool comprises about 60% of the total number of cells (Athens, Raab, Haab, Aschenbrucker, and Cartwright, 1961; Van Furth and Sluiter, 1986). The leukocytes of the marginating pool roll along the endothelial line of the vessel. This rolling is governed by the shear force of the flowing blood and the strength of the ionic bonds with the vascular endothelium (Tangelden and Afors, 1991). Under inflammatory conditions the number of rolling leukocytes in the postcapillary vesicles increases drastically. Those leukocytes adhere selectively to the endothelium. Next, these cells traverse the vessel wall between adjacent endothelial cells keeping the monolayer intact, pass the subendothelial layer and accumulate at the site of the inflammation. Strinkingly, granulocytes are commonly the first cells here, followed by the monocytes. It is obvious that knowledge of the mechanism(s) by which granulocytes and monocytes adhere to the vessel wall will enlarge therapeutic modalities (Sluiter, Pietersma, Lamers, and Koster, 1993).
KeywordsLeukocyte Adhesion Vascular Cell Adhesion Molecule Nuclear Factor kappaB Cytochrome P450 Monooxygenase Leukocyte Adhesion Molecule
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