Vitamin D pp 101-107 | Cite as

The Vitamin D Binding Protein and Its Clinical Significance

  • John G. Haddad
Part of the Nutrition and Health book series (NH)


The plasma protein that transports vitamin D and its metabolites [vitamin D binding protein (DBP)] was first recognized as a postalbumin component of human sera during electrophoretic analyses (1). Subsequently, the identity of this group-specific component (Gc-globulin) and plasma DBP was discovered (2) and confirmed (3). The protein is synthesized in the liver and displays features homologous with albumin and α-fetoprotein (4). Neither of the latter proteins binds vitamin D sterols with high affinity, however. DBP is 122 amino acids shorter than albumin and α-fetoprotein, and the genes of all three of these proteins map to human chromosome 4g11–22 (4).


Total Sterol Actin Monomer Macrophage Activate Factor Cellular Access Free Hormone Hypothesis 
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© Springer Science+Business Media New York 1999

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  • John G. Haddad

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