Vitamin D pp 375-391 | Cite as

Epidemiology of Cancer Risk and Vitamin D

  • Cedric F. Garland
  • Frank C. Garland
  • Edward D. Gorham
Part of the Nutrition and Health book series (NH)


Even though great differences exist in incidence and mortality rates of colon cancer (1) and breast cancer (2,3) according to latitude of residence, the etiologies of these cancers remain largely unexplained. Two other cancers, ovarian (4) and prostate (5–7), are also inversely related to latitude. Profound changes in incidence and mortality rates from colon and breast cancer also occur in immigrants from low-risk to high-risk areas. The rise in incidence rates occurs in the immigrants themselves for colon cancer (8), but mainly in their daughters for breast cancer (9).


Breast Cancer Prostate Cancer Colon Cancer Familial Adenomatous Polyposis Prostate Cancer Mortality 
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  1. 1.
    Garland C, Garland F. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980; 9: 227–231.PubMedCrossRefGoogle Scholar
  2. 2.
    Garland F, Garland C, Gorham E, Young J Jr. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prey Med 1990; 19: 614–622.CrossRefGoogle Scholar
  3. 3.
    Gorham E, Garland F, Garland C. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 1990; 19: 820–824.PubMedCrossRefGoogle Scholar
  4. 4.
    Lefkowitz E, Garland C. Sunlight, vitamin D, and ovarian cancer mortality rates in U.S. women. Int J Epidemiol 1994; 23: 1133–1136.PubMedCrossRefGoogle Scholar
  5. 5.
    Hanchette C, Schwartz G. Geographic patterns of prostate cancer mortality: evidence for a protective effect of ultraviolet radiation. Cancer 1992; 70: 2681–2689.CrossRefGoogle Scholar
  6. 6.
    Kafadar X. Geographic trends in prostate cancer mortality. Ann Epidemiol 1997; 7: 35–45.PubMedCrossRefGoogle Scholar
  7. 7.
    Pommerenke F, Srivastava S. State cancer control map and data program targeting cancer at the local level. In: Cancer Prevention and Control. Greenwald P, Kramer B, Weed D, eds. New York: Marcel Dekker, 1995; 771–775.Google Scholar
  8. 8.
    Haenszel W, Kurihara M. Studies of Japanese migrants. J Natl Cancer Inst 1968; 40: 43–68.PubMedGoogle Scholar
  9. 9.
    Buell P. Changing incidence of breast cancer in Japanese-American women. J Natl Cancer Inst 1973; 51: 1479–1483.PubMedGoogle Scholar
  10. 10.
    Palm T. The geographic distribution of rickets. Practitioner 1890.Google Scholar
  11. 11.
    Park E. The etiology of rickets. Physiol Rev 1924.Google Scholar
  12. 12.
    Glisson F. De Rachitide, sive, Morbo Puerili: Qui Vulgo The Rickets Dicitur Tactatus, Editio Secunda, Priori Adcuratior Lorge, and Emendatior (Treatise on Rickets, 2nd ed. ). London: Laurentii Sadler, 1660.Google Scholar
  13. 13.
    Whistler D. Disputatio Medica Inauguralis, de Morbo Puerili Anglorum, quem Patrio Idiomate Indigenae Vocant The Rickets. (University of Leiden Doctoral Dissertation). Oxford: Alexander Cooke, 1645 ca.Google Scholar
  14. 14.
    Hess A, Weinstock M, Hellman F The antirachitic value of irradiated phytosterol and cholesterol. J Biol Chem 1925; 63: 305–308.Google Scholar
  15. 15.
    Steenbock H, Black A. Fat soluble vitamins XVII. The induction of growth-promoting and calcifying properties of a ration by exposure to ultraviolet light. J Biol Chem 1924; 61: 405–422.Google Scholar
  16. 16.
    Tannenbaum A. The genesis and growth of tumors: effects of a high-fat diet. Cancer Res 1942; 2: 468.Google Scholar
  17. 17.
    Carroll K, Khor H. Effects of level and type of dietary fat on incidence of mammary tumors in female Sprague-Dawley rats by 7,12–dimethyl(a)anthracene. Lipids 1971; 6: 415–420.PubMedCrossRefGoogle Scholar
  18. 18.
    Cleave TL. The Saccharine Disease: Conditions Caused by the Taking of Refined Carbohydrates, such as Sugar and White Flour. Bristol, England: J Wright, 1974.Google Scholar
  19. 19.
    Gorham E, Garland C, Garland F. Acid haze air pollution and breast and colon cancer in 20 Canadian cities. Can J Public Health 1989; 80: 96–100.PubMedGoogle Scholar
  20. 20.
    Ziegler R. Epidemiologic patterns of colorectal cancer. In: Important advances in oncology, 1986. DeVita VT HS, Rosenberg SA, eds. Philadelphia: JP Lippincott, 1986; 209–232.Google Scholar
  21. 21.
    Mallin K, Anderson K. Cancer mortality in Illinois Mexican and Puerto Rican immigrants, 1979–1984. Int J Cancer 1988; 41: 670–676.PubMedCrossRefGoogle Scholar
  22. 22.
    Garland C, Shekelle R, Barrett-Connor E. Dietary vitamin D and calcium and risk of colorectal cancer: a 19–year prospective study in men. Lancet 1985; 1: 307–309.PubMedCrossRefGoogle Scholar
  23. 23.
    Martinez ME, Giovannucci EL, Colditz GA, Stampfer MJ, Hunter DJ, Speizer FE, Wing A, Willett WC. Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 1996; 88: 1375–1382.PubMedCrossRefGoogle Scholar
  24. 24.
    Kearney J, Giovanucci E, Rimm E, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol 1996; 143: 907–917.PubMedCrossRefGoogle Scholar
  25. 25.
    Holick M, MacLaughlin J, Clark M, et al. Photosynthesis of previtamin D3 in human skin and the physiological consequences. Science 1980; 210: 203–205.PubMedCrossRefGoogle Scholar
  26. 26.
    Holick M. The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. J Invest Dermatol 1981; 76: 51–58.CrossRefGoogle Scholar
  27. 27.
    Holick M. Photosynthesis of vitamin D in the skin: effect of environment and life-style variables. Fed Proc 1987; 46: 1876–1882.PubMedGoogle Scholar
  28. 28.
    Garland C, Comstock G, Garland F, Helsing K, Shaw E, Gorham E. Serum 25–hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 1989; 2: 1176–1178.PubMedCrossRefGoogle Scholar
  29. 29.
    Braun MM, Helzlsouer KJ, Hollis BW, Comstock GW. Colon cancer and serum vitamin D metabolite levels 10–17 years prior to diagnosis. Am J Epidemiol 1995; 142: 608–611.PubMedGoogle Scholar
  30. 30.
    Rustgi A. Hereditary gastrointestinal polyposis and non polyposis syndromes. N Engl J Med 1994; 331: 1694–1702.PubMedCrossRefGoogle Scholar
  31. 31.
    Bisgaard M, Fenger K, Bulow S, Niebuhr E, Mohr J. Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation. Hum Mutat 1994; 3: 121–125.PubMedCrossRefGoogle Scholar
  32. 32.
    Maher E, Barton D, Slatter R, et al. Evaluation of molecular genetic diagnosis in the management of familial adenomatous polyposis coli: a population based study. J Med Genet 1993; 30: 675–678.PubMedCrossRefGoogle Scholar
  33. 33.
    Konishi M, Kikuchi-Yanoshita R, Tanaka K, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996; 111: 307–317.PubMedCrossRefGoogle Scholar
  34. 34.
    Potter J, Slattery M, Bostick R, Gapstur S. Colon cancer: a review of the epidemiology. Epidemiol Rev 1993; 15: 499–545.PubMedGoogle Scholar
  35. 35.
    Potter JD. Dietary fiber, vegetables and cancer. J Nutr 1988; 118: 1591, 1592.Google Scholar
  36. 36.
    Gonzalez D. Breast Cancer Death Rates in Italy. Independent Study Project Thesis. San Diego: University of California, San Diego, School of Medicine, 1996.Google Scholar
  37. 37.
    Gorham E, Garland F, Garland C. Sunlight and breast cancer incidence in the USSR. Int J Epidemiol 1990; 19: 820–824.PubMedCrossRefGoogle Scholar
  38. 38.
    Kosary C, et al. SEER Cancer Statistics Review, 1973–1992. Publication No. 96–2798. Bethesda: National Cancer Institute, 1996; 131, 168.Google Scholar
  39. 39.
    Braun M, Helzlhauer K, Hollis B, Comstock G. Prostate cancer and prediagnostic levels of serum vitamin D metabolites. Cancer Causes Control 1995; 6: 235–239.PubMedCrossRefGoogle Scholar
  40. 40.
    Gann PH, Ma J, Hennekens CH, Hollis BW, Haddad JG, Stampfer MJ. Circulating vitamin D metabolites in relation to subsequent development of prostate cancer. Cancer Epidemiol Biomarkers Prey 1996; 5: 121–126.Google Scholar
  41. 41.
    Punnonen R, Gillespy M, Hahl M, et al. Serum 25–OHD, vitamin A and vitamin E concentrations in healthy Finnish and Floridian Women. Int J Vit Nutr Res 1988; 58: 37–39.Google Scholar
  42. 42.
    Preece M, O’Riordan J, Lawson D, Kodicek E. A competitive protein-binding assay for 25–hydroxycholecalciferol and 25–hydroxyergocalciferol in serum. Clin Chim Acta 1974; 54: 235–242.PubMedCrossRefGoogle Scholar
  43. 43.
    Sandberg JS LD, DeMandel RE, Siu W. Sulfate and nitrate particulates as related to SO2 and NOx gases and emissions. J Air Poll Control Assoc 1976; 26: 559–564.CrossRefGoogle Scholar
  44. 44.
    Waggoner A, Vanderpool A, Charlson R, et al. Sulfate light scattering as an index of the role of sulfur in tropospheric optics. Nature 1976; 261: 120–122.CrossRefGoogle Scholar
  45. 45.
    Waggoner A, Weiss RE, Ahlquist N, Covert D, Will S, Charlson R. Optical characteristics of atmospheric aerosols. Atmospheric Environ 1981; 15: 1891–1909.CrossRefGoogle Scholar
  46. 46.
    Leaderer BP Tanner R, Lioy Pi, Stolwijk JAJ. Seasonal variations in light scattering in the New York region and their relation to sources. Atmospheric Environ 1981; 15: 2407–2420.CrossRefGoogle Scholar
  47. 47.
    Lavery TF,.Hidy GM, Baskett RL, Mueller PK. The formation and regional accumulation of sulfate concentrations in the northeastern United States. In: Proceedings of a Conference on Environmental and Climatic Impact of Coal Utilization (Williamsburg VA, April 17–19, 1979). Singh JJ, Deepak A, eds. New York: Academic Press, 1980; 625–647.Google Scholar
  48. 48.
    McCartney EJ. Absorption and Emission by Atmospheric Gases: The Physical Processes. New York: Wiley, 1983.Google Scholar
  49. 49.
    Whitten RC, Prasad SS, eds. Ozone in the Free Atmosphere. New York: Van Nostrand Reinhold, 1985; 130, 131.Google Scholar
  50. 50.
    Zerefos C, Mantis H, Bais A, Ziomas I, Zoumakis N. Solar ultraviolet absorption by sulfur dioxide in Thessaloniki, Greece. Atmosphere-Ocean 1986; 24: 292–300.CrossRefGoogle Scholar
  51. 51.
    Flowers E, McCormick R, Kurfis K. J Appl Meteorol 1969; 8: 955–964.CrossRefGoogle Scholar
  52. 52.
    Middleton W. Vision Through the Atmosphere. Toronto: University of Toronto Press, 1952; 6.Google Scholar
  53. 53.
    Puzas J, Brand J. In vitro uptake of vitamin D metabolites: culture conditions determine cell uptake. Calcif Tissue Int 1985; 37: 474–477.PubMedCrossRefGoogle Scholar
  54. 54.
    Zeidman L. Chemical factors in the mutual adhesiveness of epithelial cells. Cancer Res 1947; 7: 386–389.PubMedGoogle Scholar
  55. 55.
    DeLong R, Coman D, Zeidman I. The significance of low calcium and high potassium content in neoplastic tissue. Cancer 1950; 18: 718–721.CrossRefGoogle Scholar
  56. 56.
    Lansing A, Rosenthal T, Kamen M. Calcium ion exchange in some normal tissues and in epidermal carcinogenesis. Arch Biochem 1948; 19: 177–183.PubMedGoogle Scholar
  57. 57.
    Frappart L FN, Lefebre MF, Bremond A, Vauzelle JL, Saez S. In vitro study of the effects of 1,25 dihydroxyvitamin D3 on the morphology of human breast cancer cell line BT.20. Differentiation 1989; 40: 63–69.PubMedCrossRefGoogle Scholar
  58. 58.
    Borek C, Sachs L. The difference in contact inhibition of cell replication between normal cells and cells transformed by different carcinogens. Proc Natl Acad Sci USA 1966; 56: 1705–1711.PubMedCrossRefGoogle Scholar
  59. 59.
    Stoker M. Regulation of growth and orientation in orientation in hamster cells transformed by polyoma virus. Virology 1964; 24: 165–174.PubMedCrossRefGoogle Scholar
  60. 60.
    Stoker M. Transfer of growth inhibition between normal and virus-transformed cells: autoradio-graphic studies using marked cells. J Cell Sci 1967; 2: 293–304.PubMedGoogle Scholar
  61. 61.
    Mehta P, Bertram J, Loewenstain W. Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell 1986; 44: 187–196.PubMedCrossRefGoogle Scholar
  62. 62.
    Lowenstein W. Junctional intercellular communication and the control of growth. Biochim Biophys Acta 1979; 560: 1–65.Google Scholar
  63. 63.
    Webb A, Pilbeam C, Hanofin N, Holick M. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25–hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 1990; 51: 1075–1081.PubMedGoogle Scholar
  64. 64.
    World Health Organization. Statistical Bulletin. Geneva: World Health Organization, 1995.Google Scholar
  65. 65.
    US National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Cancer Statistics Report. Bethesda, MD: National Cancer Institute, 1993; VI - 19.Google Scholar
  66. 66.
    MacLaughlin J, Anderson R, Holick M. Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. Science 1982; 216: 1001–1003.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Cedric F. Garland
  • Frank C. Garland
  • Edward D. Gorham

There are no affiliations available

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