Vitamin D pp 207-216 | Cite as

Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Implications

  • Michael F. Holick
Part of the Nutrition and Health book series (NH)


Vitamin D is synonymous with bone health and calcium metabolism. It is the biologically active vitamin D metabolite, 1, 25-dihydrovitamin D [1, 25(OH)2D; D without a subscript represents either D2 or D3] that is responsible for maintaining serum calcium levels in the normal range by increasing the efficiency of intestinal calcium absorption. When dietary calcium absorption is inadequate to satisfy the body’s requirement, then 1, 25(OH)2D mobilizes stem cells and induces them to become mature osteoclasts, which in turn mobilize calcium stores from bone to maintain serum calcium in a physiologically acceptable range (1–3).


Maintain Serum Calcium Level Dietary Calcium Absorption Chick Embryo Skeletal Muscle 
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© Springer Science+Business Media New York 1999

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  • Michael F. Holick

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