Endothelin pp 223-268 | Cite as

Pathophysiological Role of Endothelin and Potential Therapeutic Targets for Receptor Antagonists

  • David P. Brooks
  • Diane K. Jorkasky
  • Martin I. Freed
  • Eliot H. Ohlstein
Part of the Contemporary Biomedicine book series (CB)


In the decade following the discovery of endothelin (ET) by Yanagisawa and his colleagues (1), there has been a prodigious number of studies on endothelin, its receptors, and their potential role in physiological and pathophysiological processes. There is an ever-increasing literature describing the importance of endothelin and the potential use of ET-receptor antagonists in a number of diverse diseases (Table 1). A detailed description of the evidence implicating endothelin in all the diseases listed as well as citing all the relevant papers cannot be conducted within the confines of one chapter. We have, on occasion, therefore, used review articles in place of multiple citations and have concentrated our discussion on four disease areas for which there is the most evidence and provide brief descriptions of some of the other areas for which reports have appeared. As ET-receptor antagonists enter clinical development and different clinical trials are conducted, it is likely that some of these “other diseases” take more prominent positions with regard to intervention with endothelin antagonists.


Acute Renal Failure Cerebral Vasospasm Late Asthmatic Response Ischemic Acute Renal Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David P. Brooks
  • Diane K. Jorkasky
  • Martin I. Freed
  • Eliot H. Ohlstein

There are no affiliations available

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