Endothelin pp 93-119 | Cite as

Endothelin Receptor-Signaling Mechanisms in Vascular Smooth Muscle

  • E. Radford Decker
  • Tommy A. Brock
Part of the Contemporary Biomedicine book series (CB)


The local regulation of tissue blood flow depends on a delicate balance of physical and chemical stimuli acting on the vascular endothelium, the innermost lining of all blood vessels. By virtue of its location at the blood—tissue interface in vivo, vascular endothelium is ideally suited to play a pivotal role in vascular tone regulation. It is now well-documented that endothelial cells produce several vasoactive substances that activate or inhibit underlying smooth muscle cells in the blood vessel wall. Vascular smooth muscle cell (VSMC) stimulation leads to relaxation/contraction via a series of biochemical and morphological events that are responsible directly for mediating changes in vessel diameter. To date, endothelin is one of the most potent stimulators of both vascular and nonvascular smooth muscle contraction that has been identified.


Smooth Muscle Cell Vascular Smooth Muscle Vascular Smooth Muscle Cell Phorbol Ester Aortic Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • E. Radford Decker
  • Tommy A. Brock

There are no affiliations available

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