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Placental Blood

Immunology, Transplantation, and Gene Therapy
  • Anne F. Eder
  • Leslie E. Silberstein
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

Placental blood is an alternative to bone marrow for hematopoietic transplantation, and repositories of cryopreserved placental blood will be a valuable adjunct to bone marrow donor registries (1–4). Although thousands have benefitted from bone marrow transplantation since its introduction 25 year ago, only one third of patients requiring this treatment have an HLA-genotypically matched sibling (5). For those remaining, the probability of finding an HLA-identical unrelated match in a database of more than 2.6 million volunteers registered with the National Marrow Donor Program is influenced by race. The registry identifies HLA-A, -B, and -DR identical matches for approx 70% of Caucasian patients, but only for approx 34% of African American patients (6). This discrepancy is because of under representation of African Americans in the registry and increased HLA heterogeneity among African Americans compared to Caucasians. Unfortunately, even if an appropriate match is identified, some donors in the registry refuse or are medically unable to undergo the donation procedure, which requires hospitalization and anesthesia. Finally, the three to six months required to obtain bone marrow through the registry (NBMDR, personal communication) is problematic for some acutely ill patients with advancing disease or ensuing secondary complications.

Keywords

Cord Blood Umbilical Cord Blood Unrelated Donor Hematopoietic Progenitor Cell Human Umbilical Cord Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Anne F. Eder
  • Leslie E. Silberstein

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