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Molecular Mechanisms Regulating Negative Selection in Immature-Stage B-Cells

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Part of the Contemporary Immunology book series (CONTIM)

Abstract

Although the tremendous clonal diversity expressed in the B-cell receptor (BCR) repertoire is beneficial for mounting immune responses to foreign antigens, it is simultaneously detrimental in that it may include a multitude of BCRs capable of recognizing self antigens. Therefore, mechanisms must exist to functionally silence these self-reactive B-cells. Negative selection of autoreactive cells has been proposed to occur by clonal elimination or abortion (deletion), clonal silencing (anergy), and clonal alteration (receptor editing). Although there has been a significant advance in our understanding of these various modes of tolerance in recent years, the biochemical mechanisms regulating tolerance remain largely unknown. Rather than present a comprehensive review of the findings in this area, the authors will concentrate on the role of clonal deletion in the tolerization of immature B-cells. In particular, the following questions will be addressed:

  1. 1.

    Which target cell populations are sensitive to deletion?

  2. 2.

    What are the molecular mechanisms responsible for rendering these target populations tolerance sensitive? and

  3. 3.

    Is clonal deletion necessary for the maintenance of B-cell tolerance?

Keywords

  • Negative Selection
  • Antigen Receptor
  • Tolerance Induction
  • Clonal Deletion
  • Cell Antigen Receptor

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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King, L.B., Sandel, P., Sater, R.A., Monroe, J.G. (1998). Molecular Mechanisms Regulating Negative Selection in Immature-Stage B-Cells. In: Monroe, J.G., Rothenberg, E.V. (eds) Molecular Biology of B-Cell and T-Cell Development. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2778-4_21

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