Structure and Function of the Pro- and Pre-B-Cell Receptors on B-Lymphoid Lineage Precursor Cells

  • Thomas H. Winkler
  • Fritz Melchers
Part of the Contemporary Immunology book series (CONTIM)


B lymphocytes develop from hematopoietic stem cells. In mouse and in man, B lymphocyte development takes place first during embryogenesis—mainly in the fetal liver and then during postnatal life in the bone marrow (1–5). The development from progenitor (pro) and precursor (pre) B-cells to immature and mature B lymphocytes is characterized by proliferation, differentiation, and ordered rearrangements of immunoglo-bulin (Ig) heavy (H) and light (L) chain genes. As for the other hematopoietic lineages few lineage-committed progenitor cells give rise to large numbers of mature effector cells.


Light Chain Mouse Bone Marrow Chain Locus Light Chain Gene Allelic Exclusion 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Thomas H. Winkler
  • Fritz Melchers

There are no affiliations available

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