Human Langerhans Cells

  • Thomas Bieber
Chapter

Abstract

Similar to gut-associated lymphoid tissue (GALT) (1), the skin has been provided, by evolutionary pressure, with a proper immune system. The so-called skin-associated lymphoid tissue (SALT) (2) or skin immune system (SIS) (3) contains all elements required for recognition and efficient immune response against foreign structures invading this interface epithelium, which is in close contact with the environment. In this first line of immunosurveillance in the epidermis, as in other interface epithelia, professional antigen-presenting cells, i.e., dendritic cells (DC), play a key role that has been best established by studying the immunobiology of Langerhans cells (LC). In this review, we will summarize the most important aspects of these cells and discuss their physiological and pathophysiological role in IgE-mediated immune reactions. (Although the vast majority of the data has been collected in animal models, e.g., in the murine system, one should be aware that there are some important discrepancies between the human and murine LC and SIS. These will be mentioned appropriately whenever necessary.)

Keywords

Major Histocompatibility Complex Class Primary Immune Response Antigen Uptake Secondary Immune Response Skin Immune System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McWilliams M, Philips-Quagliata JM, Lamm ME (1975) Characteristics of mesenteric lymph node cells homing to gut-associated lymphoid tissue in syngeneic mice. J Immunol 115: 54–58.PubMedGoogle Scholar
  2. 2.
    Streilein, JW (1978) Lymphocyte traffic, T cell malignancies and the skin. J Invest Dermatol 71: 167–171.Google Scholar
  3. 3.
    Bos JD, Kapsenberg ML (1993) The skin immune system: progress in cutaneous biology. Immunol Today 14: 75–78.PubMedCrossRefGoogle Scholar
  4. 4.
    Langerhans P (1868) Uber die Nerven der menschlichen Haut. Virchows Arch. (Pathol Mat Physiol) 44: 325–337.Google Scholar
  5. 5.
    Birbeck MS, Breathnach AS, Everall JD (1961) An electronmicroscopic study of basal melanocytes and high-level clear cells ( Langerhans cells) in vitiligo. J Invest Dermatol 37: 51–63.Google Scholar
  6. 6.
    Stingl G, Katz SI, Clement L, Green I, Shevach EM (1978) Immunologic functions of Ia-bearing epidermal Langerhans cells. J Immunol 121: 2005–2013.PubMedGoogle Scholar
  7. 7.
    Fithian E, Kung P, Goldstein G, Rubenfeld M, Fenoglio C, Edelson, R (1981) Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sci USA 78: 2541–2544.PubMedCrossRefGoogle Scholar
  8. 8.
    Katz SI, Tamaki K, Sachs DH (1979) Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature 282: 324–326.PubMedCrossRefGoogle Scholar
  9. 9.
    Gothelf Y, Hanau D, Tsur H, Sharon N, Sahar E, Cazenave JP, Gazit E (1988) T6 positive cells in the peripheral blood of bum patients: are they Langerhans cells precursors? J Invest Dermatol 90: 142–148.PubMedCrossRefGoogle Scholar
  10. 10.
    Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360: 258–261.PubMedCrossRefGoogle Scholar
  11. 11.
    Romani N, Gruner S, Brang D, Kämpgen E, Lenz A, Trockenbacher B, Konwalika G, Fritsch P, Steinman RM, Schuler G (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180: 83–93.PubMedCrossRefGoogle Scholar
  12. 12.
    Kulmburg P, Schaefer HE, Mertelsmann R, Lindemann A (1995) Delineation of the dendritic cell lineage by generating large numbers of Birbeck granule-positive Langerhans cells from human peripheral blood progenitor cells in vitro. Blood 86: 2699–2707.PubMedGoogle Scholar
  13. 13.
    Strunk D, Rappersberger K, Egger C, Strobl H, Kromer E, Elbe A, Maurer D, Stingl G (1996) Generation of human dendritic cells Langerhans cells from circulating CD34(+) hematopoietic progenitor cells. Blood 87: 1292–1302.PubMedGoogle Scholar
  14. 14.
    Caux C, Vanbervliet B, Massacrier C, Durand I, Banchereau J (1996) Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic Langerhans cells from cord blood CD34(+) hematopoietic progenitor cells. Blood 87: 2376–2385.PubMedGoogle Scholar
  15. 15.
    Sallusto F Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte., macrophage colony-stimulating factor plus interleukin-4 and down-regulated by tumor necrosis factor-alpha. J Exp Med 179: 1109–1118.CrossRefGoogle Scholar
  16. 16.
    Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9: 271–296.PubMedCrossRefGoogle Scholar
  17. 17.
    Inaba K, Inaba M, Deguchi M, Hagi K, Yasumizu R, Ikehara S, Muramatsu S, Steinman RM (1993) Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci USA 90: 3038–3042.PubMedCrossRefGoogle Scholar
  18. 18.
    Schuler G, Steinman RM (1985) Mutine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med 161: 526–546.PubMedCrossRefGoogle Scholar
  19. 19.
    Teunissen MB, Wormmeester J, Krieg SR, Peters PJ, Vogels IM, Kapsenberg ML, Bos JD (1990) Human epidermal Langerhans cells undergo profound morphologic and phenotypical changes during in vitro culture. J Invest Dermatol 94: 166–173.PubMedCrossRefGoogle Scholar
  20. 20.
    Steinman RM and Swanson J (1995) The endocytic activity of dendritic cells. J Exp Med 182: 283–288.PubMedCrossRefGoogle Scholar
  21. 21.
    Sallusto F, Cella M, Danieli C, Lanzavecchia A (1995) Dendritic cells use macropinocytosis and the man-nose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products. J Exp Med 182: 389–400.Google Scholar
  22. 22.
    Tang A, Amagai M, Granger LG, Stanley JR, Udey MC (1993) Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361: 82–85.PubMedCrossRefGoogle Scholar
  23. 23.
    Blauvelt A, Katz SI, Udey MC (1995) Human Langerhans cells express E-cadherin. J Invest Dermatol 104: 293–296.PubMedCrossRefGoogle Scholar
  24. 24.
    Cumberbatch M, Kimber I (1995) Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology 84: 31–35.PubMedGoogle Scholar
  25. 25.
    Rupec R, Magerstaedt R, Sander E, Bieber T (1996) Granulocyte., macrophage-colony stimulating factor induces the migration of human epidermal Langerhans cells. Exp Dermatol 5: 115–119.PubMedCrossRefGoogle Scholar
  26. 26.
    Heufler C, Koch F, Schuler G (1988) Granulocyte., macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells. J Exp Med 167: 700–705.PubMedCrossRefGoogle Scholar
  27. 27.
    Strobel I, Rupec R, Wollenberg A, Bieber T (1993) IL-2 receptor on human Langerhans cells lacks the (3-chain but mediates IL-2 dependent migration: evidence for a putative y-chain. Arch Dermatol Res 285: 108Google Scholar
  28. 28.
    Inaba K, Steinman RM (1986) Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering. J Exp Med 163: 247–261.Google Scholar
  29. 29.
    Romani N, Lenz A, Glassel H, Stossel H, Stanzl U, Majdic O, Fritsch P, Schuler G (1989) Cultured human Langerhans cells ressemble lymphoid dendritic cells in phenotype and function. J Invest Dermatol 93: 600–609.PubMedCrossRefGoogle Scholar
  30. 30.
    Luger TA, Schwarz T (1993) Epidermal growth factors and cytokines. Marcel Dekker, New York, 1993.Google Scholar
  31. 31.
    Wollenberg A, Wen SP, Bieber T (1995) Langerhans cells phenotyping: A new tool for the differential diagnosis of eczematous skin diseases. Lancet 346: 1626–1627.Google Scholar
  32. 32.
    Wollenberg A, Kraft S, Hanau D, Bieber T (1996) Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell ( IDEC) population in lesional skin of atopic eczema. J Invest Dermatol 106: 446–453.Google Scholar
  33. 33.
    Kripke ML (1991) Immunological effects of ultraviolet radiation. J Dermatol 18: 429–433.PubMedGoogle Scholar
  34. 34.
    Saijo S, Bucana CD, Ramirez KM, Cox PA, Kripke ML, Strickland FM (1995) Deficient antigen presentation and Ts induction are separate effects of ultraviolet irradiation. Cell Immunol 164: 189–202.PubMedCrossRefGoogle Scholar
  35. 35.
    Enk AH, Katz SI (1992) Identification and induction of keratinocyte-derived IL-10. J Immunol 149: 92–95.PubMedGoogle Scholar
  36. 36.
    Enk CD, Sredni D, Blauvelt A, Katz SI (1995) Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 154: 4851–4856.PubMedGoogle Scholar
  37. 37.
    Grewe M, Gyufko K, Krutman J (1995) Interleukin-10 production by cultured human keratinocytes and their modulation by ultraviolet B and ultraviolet Al. J Invest Dermatol 104: 3–6.PubMedCrossRefGoogle Scholar
  38. 38.
    Jackson M, Thomson KE, Laker R, Norval M, Hunter J, Mc Kenzie RC (1996) Lack of induction of IL-10 expression in human keratinocytes. J Invest Dermatol 106: 1329–1330.Google Scholar
  39. 39.
    Schreiber S, Kilgus O, Payer E, Kutil R, Elbe A, Mueller C, Stingl G (1992) Cytokine pattern of Langerhans cells isolated from murine epidermal cell cultures. J Immunol 149: 3524–3534.PubMedGoogle Scholar
  40. 40.
    Romani N, Kampgen E, Koch F, Heufler C, Schuler G (1990) Dendritic cell production of cytokines and responses to cytokines. hit Rev Immunol 6: 151–161.Google Scholar
  41. 41.
    Sauder DN, Dinarello CA, Morhenn VB (1984) Langerhans cell production of interleukin-1. J Invest Dermatol 82: 605–607.PubMedCrossRefGoogle Scholar
  42. 42.
    Larrick JW, Morhenn V, Chiang YL, Shi T (1989) Activated Langerhans cells release tumor necrosis factor. J Leukoc Biol 45: 429–433.PubMedGoogle Scholar
  43. 43.
    Bieber T, Sticherling M, Rupec R, Schroeder JM (1991) Human epidermal Langerhans cells release the neutrophil activating peptide IL-8. J Invest Dermatol 96: 1013.Google Scholar
  44. 44.
    Bieber T, de la Salle H, Wollenberg A, Hakimi J, Chizzonite R, Ring J, Hanau D, de la Salle C (1992) Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E ( FcERI ). J Exp Med 175: 1285–1290.Google Scholar
  45. 45.
    Wang B, Rieger A, Kilgus O, Ochiai K, Maurer D, Fodinger D, Kinet JP, Stingl G (1992) Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI. J Exp Med 175: 1353–1365.PubMedCrossRefGoogle Scholar
  46. 46.
    Bieber T (1996) Fc epsilon R1 on human antigen presenting cells. Curr Opin Immunol 18: 773–777.CrossRefGoogle Scholar
  47. 47.
    Mudde GC, Hansel TT, V.Reijsen FC, Osterhoff BF, Bruijnzeel-Koomen CAFM (1990) IgE: an immunoglobulin specialized in antigen capture. Immunol Today 11: 440–443.PubMedCrossRefGoogle Scholar
  48. 48.
    Jurgens M, Wollenberg A, Hanau D, De la Salle H, Bieber T (1995) Activation of human epidermal Langerhans cells by engagement of the high affinity receptor for IgE, FceRI. J Immunol 155: 5184–5189.Google Scholar
  49. 49.
    Bonnerot C, Lamkar D, Hanau D, Spehne D, Davoust J, Salamero J, Fridman WH (1995) Role of B-cell receptor Ig alpha and Ig beta subunits in MHC class II restricted antigen presentation. Immunity 3: 335–347.PubMedCrossRefGoogle Scholar
  50. 50.
    Mudde GC, van-Reijsen FC, Boland GJ, de-Gast GC, Bruijnzeel PL, Bruijnzeel-Koomen CA (1990) Allergen presentation by epidermal Langerhans cells from patients with atopic dermatitis is mediated by IgE. Immunology 69: 335–341.PubMedGoogle Scholar
  51. 51.
    Maurer D, Fiebiger E, Reininger B, Wolffwiniski B, Jouvin MH, Kilgus O, Kinet JP, Stingl G (1994) Expression of functional high affinity immunoglobulin E receptors ( FceRI) on monocytes of atopic individuals. J Exp Med 179: 745–750.Google Scholar
  52. 52.
    Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP, Stingl G (1995) The high affinity IgE receptor ( Fc RI) mediates IgE-dependent allergen presentation. J Immunol 154: 6285–6290.Google Scholar
  53. 53.
    Maurer D, Fiebiger E, Ebner C, Reininger B, Fischer GF, Wichlas S, Jouvin M-H, Schmitt-Egenolf M, Kraft D, Kinet J-P, Stingl G (1996) Peripheral blood dendritic cells express FceRI as a complex composed of FceRIa-and FceRIy-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 157: 607–616.PubMedGoogle Scholar
  54. 54.
    Bieber T (1997) FceRI on human epidermal Langerhans cells: an old receptor with new structure and functions. Int Arch All Clin Immunol 113: 30–34.CrossRefGoogle Scholar
  55. 55.
    Galli SJ, Costa JJ (1995) Mast-cell-leukocyte cytokine cascades in allergic inflammation. Allergy 50: 851–862.PubMedCrossRefGoogle Scholar
  56. 56.
    Bruijnzeel-Koomen C, van Reysen F, Mudde GC (1991) IgE and atopic dermatitis. Clin Exp Allergy 21-(Suppl) 1: 294–301.CrossRefGoogle Scholar
  57. 57.
    Bieber T (1995) Role of Langerhans cells in the pathophysiology of atopic dermatitis. Pathol Biol 43: 871–875.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1998

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  • Thomas Bieber

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