The Role of the Bone Marrow in Allergic Disease

  • Mark D. Inman
  • Roma Sehmi
  • Paul M. O’Byrne
  • Judah A. Denburg


A current understanding of the pathogenesis of allergen-induced airway diseases is presented in several chapters in this book. These events are schematically summarized in Fig. 1. The development of airway inflammation occurs in response to the multiple actions of mediators released primarily from mast cells and T-helper 2 (Th2) cells, including autocrine upregulation and recruitment of inflammatory cells via target cell priming, adhesion molecule activation, chemotaxis, target cell activation, and decreased apoptosis. All of these well-recognized mechanisms are concerned with the movement of cells or activation of cells in the airway. Little attention has been paid to the source of these inflammatory cells as a mechanism in allergic inflammation.


Mast Cell Allergic Disease Allergy Clin Immunol Allergen Challenge Airway Hyperresponsiveness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Mark D. Inman
  • Roma Sehmi
  • Paul M. O’Byrne
  • Judah A. Denburg

There are no affiliations available

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