Airway Remodeling and Repair

  • Peter M. Hockey
  • Ratko Djukanović
  • William R. Roche
  • Steven T. Holgate
Chapter

Abstract

It is now universally accepted that asthma is a disease process revolving around inflammation and its effects on airway pathophysiology. The inflammatory features of asthma are characterized by immunohistological and cytokine profiles that appear to be specific for asthma and, importantly, are not demonstrable in the nonatopic, nonasthmatic, normal individual. They have been shown to include edema, hyperplasia of mucus-secreting cells, hypertrophy of smooth muscle, collagen deposition beneath the epithelial basement membrane, intraluminal cellular and mucus debris, cellular infiltration of the epithelium, and sloughing of the epithelial cell layer with subsequent denudation of the normal air-tissue interface. These changes have been shown to be present to a varying degree in patients with mild, asymptomatic disease right through to those dying in status asthmaticus. Although considerable attention has focused on the documentation of morphological abnormalities, especially by means of bronchial biopsy studies, to date comparatively little attention has been paid to the healing process. As with inflammatory processes in other tissues, chronic insult to the airways is likely to lead to a cycle of inflammation and repair, although the factors that determine the balance between the two remain largely unknown (1).

Keywords

Mast Cell Allergy Clin Immunol Respir Crit Bronchial Epithelial Cell Airway Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Peter M. Hockey
  • Ratko Djukanović
  • William R. Roche
  • Steven T. Holgate

There are no affiliations available

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