Pathogenesis of Asthma

  • Paul M. O’Byrne


Asthma is a common disease, with a prevalence of 5–10% in most countries in which this has been studied. In addition, in some, particularly younger, populations the prevalence of asthma is increasing. This trend has been recognized in children in Australia (1), New Zealand (2), and the United Kingdom (3). These increases may result from changes in diagnostic labeling and subsequent treatment strategies or from a real increase in prevalence due to an increase in exposure to risk factors in a susceptible population. Support for the latter suggestion comes from studies that have described an increase in hospitalizations in children for severe asthma in the United States (4) and the epidemics of asthma deaths that occurred in several countries in the early 1980s (5).


Airway Inflammation Allergy Clin Immunol Airway Hyperresponsiveness Eosinophil Cationic Protein Asthmatic Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Paul M. O’Byrne

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