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Pathogenesis of Asthma

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Allergy and Allergic Diseases

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Abstract

Asthma is a common disease, with a prevalence of 5–10% in most countries in which this has been studied. In addition, in some, particularly younger, populations the prevalence of asthma is increasing. This trend has been recognized in children in Australia (1), New Zealand (2), and the United Kingdom (3). These increases may result from changes in diagnostic labeling and subsequent treatment strategies or from a real increase in prevalence due to an increase in exposure to risk factors in a susceptible population. Support for the latter suggestion comes from studies that have described an increase in hospitalizations in children for severe asthma in the United States (4) and the epidemics of asthma deaths that occurred in several countries in the early 1980s (5).

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References

  1. Robertson CF, Heycock E, Bishop J, Nolan T, Olinsky A, Phelan P (1991) Prevalence of asthma in Melbourne schoolchildren: changes over 26 years. Br Med J 302: 1116–1118.

    CAS  Google Scholar 

  2. Burrows B, Sears MR, Flannery EM, Herbison GP, Holdaway MD (1995) Relations of bronchial responsiveness to allergy skin test reactivity, lung function, respiratory symptoms, and diagnoses in thirteen-year-old New Zealand children. J Allergy Clin Immunol 95: 548–556.

    PubMed  CAS  Google Scholar 

  3. Burney PGJ, Chinn S, Rona RJ (1990) Has the prevalence of asthma increased in childhood? Evidence from the national study of health and growth 1973–86. Br Med J 300: 1306–1310.

    CAS  Google Scholar 

  4. Gerstman BB, Bosco LA, Tomita DK (1993) Trends in the prevalence of asthma hospitalization in the 5- to 14-year-old Michigan Medicaid population, 1980 to 1986. J Allergy Clin Immunol 91: 838–843.

    PubMed  CAS  Google Scholar 

  5. Sears MR, Rea HH, Rothwell RPG, O’Donnell TV, Holst PE, Gillies AJD, Beaglehole R (1986) Asthma mortality: comparison between New Zealand and England. Br Med J 293: 1342–1345.

    CAS  Google Scholar 

  6. Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE (1977) Bronchial reactivity of inhaled histamine: a method and clinical survey. Clin Allergy 7: 235–243.

    PubMed  CAS  Google Scholar 

  7. Hargreave FE, Ramsdale EH, Pugsley SO (1984) Occupational asthma without bronchial hyperresponsiveness. Am Rev Respir Dis 130: 513–515.

    PubMed  CAS  Google Scholar 

  8. Cockcroft DW, Berscheid BA, Murdock KY (1983) Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest 83: 751–754.

    PubMed  CAS  Google Scholar 

  9. Juniper EF, Frith PA, Hargreave FE (1982) Long term stability of bronchial responsiveness to histamine. Thorax 37: 288–291.

    PubMed  CAS  Google Scholar 

  10. Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE (1982) Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol 70: 170–177.

    PubMed  CAS  Google Scholar 

  11. Boulet LP, Cartier A, Thomson NC, Roberts RS, Dolovich J, Hargreave FE (1983) Asthma and increases in nonallergic bronchial responsiveness from seasonal pollen exposure. J Allergy Clin Immunol 71: 399–406.

    PubMed  CAS  Google Scholar 

  12. Golden JA, Nadel JA, Boushey HA (1978) Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis 118: 287–294.

    PubMed  CAS  Google Scholar 

  13. Fabbri LM, Boschetto P, Zocca E, Milani G, Pivirotto F, Plebani M, Burlina A, Licata B, Mapp CE (1987) Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am Rev Respir Dis 136: 36–42.

    PubMed  CAS  Google Scholar 

  14. Chan-Yeung M, Lam S, Koener S (1982) Clinical features and natural history of occupational asthma due to western red cedar ( Thuja plicata ). Am J Med 72: 411–415.

    Google Scholar 

  15. Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA (1976) Mechanisms of bronchial hyper-reactivity in normal subjects after upper respiratory tract infections. Am Rev Respir Dis 113: 131–139.

    PubMed  CAS  Google Scholar 

  16. Juniper EF, Frith PA, Hargreave FE (1981) Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 36: 575–579.

    PubMed  CAS  Google Scholar 

  17. Sears MR, Jones DT, Holdaway MD, Hewitt CJ, Flannery EM, Herbison GP, Silva PA (1986) Prevalence of bronchial reactivity to inhaled methacholine in New Zealand children. Thorax 41: 283–289.

    PubMed  CAS  Google Scholar 

  18. Salome CM, Peat J, Britton WJ, Woolcock AJ (1987) Bronchial hyperresponsiveness in two populations of Australian schoolchildren. Clin Allergy 17: 271–281.

    PubMed  CAS  Google Scholar 

  19. Ryan G, Latimer KM, Dolovich J, Hargreave FE (1982) Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rates and improvement after bronchodilators. Thorax 37: 423–429.

    PubMed  CAS  Google Scholar 

  20. Ramsdale EH, Moms MM, Roberts RS, Hargreave FE (1984) Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax 39: 912–918.

    PubMed  CAS  Google Scholar 

  21. Anderton RC, Cuff MT, Frith PA, Cockcroft DW, Morse JLC, Jones NL, Hargreave FE (1979) Bronchial responsiveness to inhaled histamine and exercise. J Allergy Clin Immunol 63: 315–320.

    PubMed  CAS  Google Scholar 

  22. O’Byrne PM, Ryan G, Morris M, McCormack D, Jones NL, Morse JLC, Hargreave FE (1982) Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine. Am Rev Respir Dis 125: 281–285.

    PubMed  Google Scholar 

  23. Brand PL, Rijcken B, Schouten JP, Koeter GH, Weiss ST, Postma DS (1992) Perception of airway obstruction in a random population sample. Relationship to airway hyperresponsiveness in the absence of respiratory symptoms. Am Rev Respir Dis 146: 396–401.

    Google Scholar 

  24. van Haren EH, Lammers JW, Festen J, Heijerman HG, Groot CA, van Herwaarden L (1995) The effects of the inhaled corticosteroid budesonide on lung function and bronchial hyperresponsiveness in adult patients with cystic fibrosis. Respir Med 89: 209–214.

    PubMed  Google Scholar 

  25. White AM, Stevens WH, Upton AR, O’Byrne PM, Collins SM (1991) Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome. Gastroentrology 100: 68–74.

    CAS  Google Scholar 

  26. Longo G, Strinati R, Poli F, Fumi F (1987) Genetic factors in nonspecific bronchial hyperreactivity. An epidemiologic study. Am J Dis Child 141: 331–334.

    Google Scholar 

  27. Hopp RJ, Bewtra AK, Biven R, Nair NM, Townley RG (1988) Bronchial reactivity pattern in nonasthmatic parents of asthmatics. Ann Allergy 61: 184–186.

    PubMed  CAS  Google Scholar 

  28. Clifford RD, Pugsley A, Radford M, Holgate ST (1987) Symptoms, atopy, and bronchial response to methacholine in parents with asthma and their children. Arch Dis Child 62: 66–73.

    PubMed  CAS  Google Scholar 

  29. Peat JK, Britton WJ, Salome CM, Woolcock AJ (1987) Bronchial hyperresponsiveness in two populations of Australian schoolchildren. II. Relative importance of associated factors. Clin Allergy 17: 283–290.

    Google Scholar 

  30. Zamel N, Leroux M, Vanderdoelen JL (1984) Airway response to inhaled methacholine in healthy nonsmoking twins. J Appl Physiol 56: 936–939.

    PubMed  CAS  Google Scholar 

  31. Nieminen MM, Kaprio J, Koskenvuo M (1991) A population-based study of bronchial asthma in adult twin pairs. Chest 100: 70–75.

    PubMed  CAS  Google Scholar 

  32. Young S, Le Souef PN, Geelhoed GC, Stick SM, Turner KJ, Landau LI (1991) The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. N Engl J Med 324: 1168–1173.

    PubMed  CAS  Google Scholar 

  33. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC (1995) Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 333: 894–900.

    PubMed  CAS  Google Scholar 

  34. van Herwerden L, Harrap SB, Wong ZYH, Abramson MJ, Kutin JJ, Forbes AB, Raven J, Lanigan A, Walters EH (1995) Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet 346: 1262–1265.

    PubMed  Google Scholar 

  35. Hall W, Wheatley A, Wilding P, Liggett SB (1995) Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345: 1213–1214.

    PubMed  CAS  Google Scholar 

  36. Turki J, Pak J, Green SA, Martin RJ, Liggett SB (1995) Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly 16 correlates with the nocturnal phenotype. J Clin Invest 95: 1635–1641.

    PubMed  CAS  Google Scholar 

  37. Peat JK, Tovey E, Gray EJ, Mellis CM, Woolcock AJ (1994) Asthma severity and morbidity in a population sample of Sydney schoolchildren: Part II-Importance of house dust mite allergens. Aust NZ J Med 24: 270–276.

    Google Scholar 

  38. Peat JK, Salome CM, Woolcock AJ (1990) Longitudinal changes in atopy during a 4-year period: relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren. J Allergy Clin Immunol 85: 65–74.

    PubMed  CAS  Google Scholar 

  39. Sherrill D, Sears MR, Lebowitz MD, Holdaway MD, Hewitt CJ, Flannery EM, Herbison GP, Silva PA (1992) The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study. Pediatr Pulmonol 13: 78–85.

    PubMed  CAS  Google Scholar 

  40. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ (1990) Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med 323: 502–507.

    Google Scholar 

  41. Stevens FA (1934) A comparison of pulmonary and dermal sensitivity to inhaled substances. J Allergy 5: 285–288.

    Google Scholar 

  42. Herxheimer H (1952) The late bronchial reaction in induced asthma. Int Arch Allergy 3: 323–328.

    PubMed  CAS  Google Scholar 

  43. Altounyan REC (1970) Changes in histamine and atropine responsiveness as a guide to diagnosis and evaluation of therapy in obstructive airways disease. In: Pepys J, Franldand AW, eds. Disodium Cromoglycate in Allergic Airways Disease. Butterworth, London, pp. 47–53.

    Google Scholar 

  44. Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE (1977) Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy 7: 503–513.

    PubMed  CAS  Google Scholar 

  45. Chan-Yeung M, Lam S (1986) Occupational asthma: state of the art. Am Rev Respir Dis 133: 686–703.

    PubMed  CAS  Google Scholar 

  46. Platts-Mills TA, Mitchell EB, Nock P, Tovey ER, Moszor H, Wilkins S (1982) Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet 2: 675–678.

    PubMed  CAS  Google Scholar 

  47. Osler W (1892) The Principle and Practice of Medicine. Appleton, New York, p. 497.

    Google Scholar 

  48. Dunnill MS, Massarell GR, Anderson JA (1969) A comparison of the quantitive anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis and in emphysema. Thorax 24: 176–179.

    PubMed  CAS  Google Scholar 

  49. Stelzer J, Bigby BG, Stulbarg M, Holtzman MJ, Nadel JA, Ueki IF, Leikauf GD, Goetzl EJ, Boushey HA (1986) Ozone-induced changes in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 60: 1231–1326.

    Google Scholar 

  50. Fabbri LM, Boschetto P, Zocca E, Milani G, Pivirotto F, Plebani M, Burlina A, Licata B, Mapp CE (1987) Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate. Am Rev Respir Dis 136: 36–42.

    PubMed  CAS  Google Scholar 

  51. DeMonchy JGR, Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ, DeVries K (1985) Bronchoalveolar eosinophilia during allergen-induced late asthmatic reaction. Am Rev Respir Dis 131: 373–376.

    CAS  Google Scholar 

  52. Lam S, LeRiche J, Phillips D, Chan-Yeung M (1987) Cellular and protein changes in bronchial lavage fluid after late asthmatic reaction in patients with red cedar asthma J Allergy Clin Immunol 80: 44–50.

    CAS  Google Scholar 

  53. Metzger WJ, Zavala D, Richerson HB, Moseley P, Iwamota P, Monick M, Sjoerdsma K, Hunnunghake GW (1987) Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Am Rev Respir Dis 135: 433–440.

    PubMed  CAS  Google Scholar 

  54. Diaz P, Gonzalez MC, Galleguillos FR, Ancic P, Cromwell O, Shepherd D, Durham SR, Gleich GJ, Kay AB (1989) Leucocytes and mediators in bronchoalveolar lavage during allergen-induced late-phase asthmatic reactions. Am Rev Respir Dis 139: 1383–1389.

    PubMed  CAS  Google Scholar 

  55. Aalbers R, Kauffman HK, Vrugt B, Smith M, Koeter G, Timens W, De Monchy JGR (1993) Bronchial lavage and bronchoalveolar lavage in allergen-induced single early and dual asthmatic responses. Am Rev Respir Dis 147: 76–81.

    PubMed  CAS  Google Scholar 

  56. Woolley KL, Adelroth E, Woolley MJ, Ellis R, Jordana M, O’Byrne PM (1995) Effects of allergen challenge on eosinophils, eosinophil cationic protein and granulocyte-macrophage colony-stimulating factor in mild asthma. Am J Respir Crit Care Med 151: 1915–1924.

    PubMed  CAS  Google Scholar 

  57. Gizycki M, Ädelroth E, Rogers A, O’Byrne PM, Jeffery PK (1997) Myofibroblast involvement in the allergen-induced late response in mild atopic asthma. Am J Respir Cell Mol Biol 16: 664–673.

    PubMed  CAS  Google Scholar 

  58. Gibson PG, Girgis-Gabardo A, Hargreave FE, Morris MM, Mattoli S, Kay JM, Dolovich J, Denberg J (1989) Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax 44: 693–699.

    PubMed  CAS  Google Scholar 

  59. Pin I, Freitag AP, O’Byrne PM, Girgis-Gabardo A, Watson RM, Dolovich J, Denberg JA, Hargreave FE (1992) Changes in the cellular profile of induced sputum after allergen-induced asthmatic responses. Am Rev Respir Dis 145: 1265–1269.

    PubMed  CAS  Google Scholar 

  60. Gibson PG, Manning PJ, O’Byme PM, Girgis-Gabardo A, Denburg JA, Hargreave FE (1991) Allergen-induced asthmatic responses: relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils and their progenitors. Am Rev Respir Dis 143: 331–335.

    PubMed  CAS  Google Scholar 

  61. Woolley MJ, Denburg JA, Ellis R, Dahlback M, O’Byrne PM (1994) Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters. Am J Respir Cell Mol Biol 11: 600–606.

    PubMed  CAS  Google Scholar 

  62. Kirby JG, Hargreave FE, Gleich GJ, O’Byrne PM (1987) Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects. Am Rev Respir Dis 136: 379–383.

    PubMed  CAS  Google Scholar 

  63. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB (1988) Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Am Rev Respir Dis 137: 62–69.

    PubMed  CAS  Google Scholar 

  64. Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, Venge P, Ahlstedt S, Simony Lafontaine J, Godard P, et al. (1990) Eosinophilic inflammation in asthma. N Engl J Med 323: 1033–1039.

    PubMed  CAS  Google Scholar 

  65. Woolley KL, Adelroth E, Woolley MJ, Ellis R, Jordana M, O’Byrne PM (1994) Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in mild asthmatics and non-asthmatics. Eur Respir J 7: 1576–1584.

    PubMed  CAS  Google Scholar 

  66. Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139: 806–817.

    PubMed  CAS  Google Scholar 

  67. Jeffery PK, Wardlaw AJ, Nelson F, Collins JV, Kay AB (1989) Bronchial biopsies in asthma. An ultra-structural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 140: 1745–1753.

    Google Scholar 

  68. Azzawi M, Bradley B, Jeffery PK, et al. (1990) Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 142: 1407–1413.

    PubMed  CAS  Google Scholar 

  69. Poston RN, Chanez P, Lacoste JY, Litchfield T, Lee TH, Bousquet J (1992) Immunohistochemical characterization of the cellular infiltration in asthmatic bronchi. Am Rev Respir Dis 145: 918–921.

    PubMed  CAS  Google Scholar 

  70. Kelly C, Ward C, Stenton CS, Bird G, Hendrick PJ, Walters EH (1988) Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway hyperresponsiveness. Thorax 43: 684–692.

    PubMed  CAS  Google Scholar 

  71. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB (1992) Predominant TH2-like bronchoalveolar T-lymphocyte populations in atopic asthma N Engl J Med 326: 298–304.

    CAS  Google Scholar 

  72. Takanashi S, Nonaka R, Xing Z, O’Byrne PM, Dolovich J, Jordana M (1994) Interleukin 10 inhibits LPS-induced survival and cytokine production by human peripheral blood eosinophils. J Exp Med 180: 711–715.

    Google Scholar 

  73. Nonaka M, Nonaka R, Woolley K, Adelroth E, Miura K, O’Byrne PM, Dolovich J, Jordana M (1995) Distinct immunohistochemical localization of IL-4 in human inflammed airway tissues. J Immunol 155: 3234–3244.

    PubMed  CAS  Google Scholar 

  74. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR (1993) Increases in activated T-lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/ macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am J Respir Cell Mol Biol 8: 35–42.

    PubMed  CAS  Google Scholar 

  75. Broide DH, Paine MM, Firestein GS (1992) Eosinophils express interleukin 5 and granulocyte-macrophage colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 90: 1414–24.

    PubMed  CAS  Google Scholar 

  76. Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, et al. (1991) Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma J Clin Invest 87: 1541–1546.

    CAS  Google Scholar 

  77. Woolley KL, Adelroth E, Woolley MJ, Ramis I, Abrams JS, Jordana M, O’Byrne PM (1996) Interleukin-3 in bronchial biopsies from non-asthmatics and patients with mild and allergen-induced asthma. Am J Resp Crit Care Med 153: 350–355.

    PubMed  CAS  Google Scholar 

  78. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Resp Dis 131: 599–606.

    PubMed  CAS  Google Scholar 

  79. Gleich GJ, Frigas E, Loegering DA, et al. (1979) Cytotoxic properties of the eosinophil major basic protein. J Immunol 123: 2925–2927.

    PubMed  CAS  Google Scholar 

  80. O’Byrne PM, Dolovich M, Dirks R, Roberts RS, Newhouse MT (1984) Lung epithelial permeability: Relation to nonspecific airway responsiveness. J Appl Physiol 57 (1): 77–84.

    PubMed  Google Scholar 

  81. Flavahan NA, Aarhuus LL, Rimele TJ, Vanhoutte PM (1985) Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol 58: 834–838.

    PubMed  CAS  Google Scholar 

  82. Leikauf GD, Ueki IF, Nadel JA, Widdicombe JH (1985) Bradykinin stimulates CI secretion and prostaglandin E2 release by canine tracheal epithelium. Am J Physiol 248: F48 - F55.

    PubMed  CAS  Google Scholar 

  83. Walters EH, O’Byrne PM, Fabbri LM, Graf PD, Holtzman MJ, Nadel JA (1984) Control of neurotransmission by prostaglandins in canine trachealis smooth muscle. J Appl Physiol 57: 129–134.

    PubMed  CAS  Google Scholar 

  84. Manning PJ, Lane CG, O’Byrne PM (1989) The effect of oral prostaglandin E1 on airway responsiveness in asthmatic subjects. Pulmonary Pharmacol 2: 121–124.

    CAS  Google Scholar 

  85. Melillo E, Woolley KL, Manning PJ, Watson RM, O’Byrne PM (1994) Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects. Am J Respir Crit Care Med 149: 1138–1141.

    PubMed  CAS  Google Scholar 

  86. Pavord ID, Wong CS, Williams J, Tattersfield AE (1993) Effect of inhaled prostaglandin E2 on allergen-induced asthma. Am Rev Respir Dis 148: 87–90.

    PubMed  CAS  Google Scholar 

  87. Dusser DJ, Jacoby DB, Djokic TD, Rubinstein I, Borson DB, Nadel JA (1989) Virus induces airway hyperresponsiveness to tachykinins• role of neutral endopeptidase. J Appl Physiol 67: 1504–1511.

    PubMed  CAS  Google Scholar 

  88. James Al, Pare PD, Hogg JC (1989) The mechanics of airway narrowing in asthma. Am Rev Respir Dis 139: 242–246.

    Google Scholar 

  89. Menon PK, Stankus RP, Rando RJ, Salvaggio JE, Lehrer SB (1991) Asthmatic responses to passive cigarette smoke: persistence of reactivity and effect of medications. J Allergy Clin Immunol 88: 861–869.

    PubMed  CAS  Google Scholar 

  90. Higgins BG, Francis HC, Yates CJ, Warburton CJ, Fletcher AM, Reid JA, Pickering CA, Woodcock AA (1995) Effects of air pollution on symptoms and peak expiratory flow measurements in subjects with obstructive airways disease. Thorax 50: 149–155.

    PubMed  CAS  Google Scholar 

  91. Moseler M, Hendel Kramer A, Karmaus W, Forster J, Weiss K, Urbanek R, Kuehr J (1994) Effect of moderate NO2 air pollution on the lung function of children with asthmatic symptoms. Environ Res 67: 109–124.

    PubMed  CAS  Google Scholar 

  92. Chandler-Deal E Jr, McFadden ER Jr, Ingram RH Jr, Breslin FJ, Jaegar JJ (1980) Airways responsiveness to cold air and hyperventilation in normal subjects and in those with hayfever and asthma. Am Rev Respir Dis 121: 621–628.

    Google Scholar 

  93. Anderson SD (1985) Exercise-induced asthma. The state of the art. Chest 875: 191–195.

    Google Scholar 

  94. Stevenson DD (1984) Diagnosis, prevention and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. J Allergy Clin Immunol 74: 617–622.

    PubMed  CAS  Google Scholar 

  95. Dahlen SE, Hedqvist P, Hammarstrom S, Samuelsson B (1980) Leukotrienes are potent constrictors of human bronchi. Nature 288: 484–486.

    PubMed  CAS  Google Scholar 

  96. Adelroth E, Morris MM, Hargreave FE, O’Byrne PM (1986) Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls. N Engl J Med 315: 480–484.

    PubMed  CAS  Google Scholar 

  97. Manning PJ, Rokach J, Malo JL, Ethier D, Cartier A, Girard Y, Charleson S, O’Byrne PM (1990) Urinary leukotriene E4 levels during early and late asthmatic responses. J Allergy Clin Immunol 86: 211–20

    PubMed  CAS  Google Scholar 

  98. Taylor GW, Black P, Turner N, Taylor I, Maltby NH, Fuller RW, Dollery CT (1989) Urinary leukotriene E4 after antigen challenge and in acute asthma and allergic rhinitis. Lancet i: 584–587.

    Google Scholar 

  99. Kumlin M, Dahlen B, Bjorck T, Zetterstrom O, Granstrom E, Dahlen S-E (1992) Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4 and histamine in asthmatics. Am Rev Respir Dis 146: 96–103.

    PubMed  CAS  Google Scholar 

  100. Manning PJ, Watson RM, Margolskee DJ, Williams V, Schartz JI, O’Byrne PM (1990) Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4 receptor antagonist. N Engl J Med 323: 1736–1739.

    PubMed  CAS  Google Scholar 

  101. Taylor IK, O’Shaughnessy KM, Fuller RW, Dollery CT (1991) Effect of a cysteinyl leukotriene receptor antagonist, ICI 204–219, on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 337: 690–694.

    PubMed  CAS  Google Scholar 

  102. Israel E, Dermarkarian R, Rosenberg M, et al. (1990) The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med 323: 1740–1744.

    PubMed  CAS  Google Scholar 

  103. Israel E, Fischer AR, Rosenburg MA, Lilly CM, Callery JC, Shapiro J, Cohn J, Rubin R, Drazen JM (1993) The pivitol role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis 148: 1447–1451.

    PubMed  CAS  Google Scholar 

  104. Gaddy J, Bush RK, Margolskee D, Williams VC, Busse W (1992) The effects of a leukotriene D4 (LTD4) antagonist (MK-571) in mild to moderate asthma. Am Rev Respir Dis 146: 358–363.

    PubMed  CAS  Google Scholar 

  105. Hui KP, Barnes NC (1991) Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist. Lancet 337: 1062–1063.

    PubMed  CAS  Google Scholar 

  106. Israel E, Rubin P, Kemp JP, et al. (1993) The effect of inhibition of 5-lipoxygenase by Zileuton in mild-to-moderate asthma. Ann Intern Med 119: 1059–1066.

    PubMed  CAS  Google Scholar 

  107. Spector SL, Smith LJ, Glass M (1994) Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. Am J Respir Crit Care Med 150: 618–623.

    PubMed  CAS  Google Scholar 

  108. Laitinen LA, Laitinen A, Haahtela T, Vilkka V, Spur BW, Lee TH (1993) Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 341: 989–990.

    PubMed  CAS  Google Scholar 

  109. Barnes PJ (1986) State of the art: neural control of human airways in health and disease. Am Rev Respir Dis 134: 1289–1314.

    PubMed  CAS  Google Scholar 

  110. Hartley JPR, Nogrady SG (1980) Effect of an inhaled antihistamine on exercise-induced asthma Thorax 35: 675–679.

    CAS  Google Scholar 

  111. Bousquet J, Godard P, Michel FB (1992) Antihistamines in the treatment of asthma. Eur Respir J 5: 1137–1142.

    PubMed  CAS  Google Scholar 

  112. Manning PJ, Stevens WH, Cockcroft DW, O’Byrne PM (1991) The role of thromboxane in allergen-induced asthmatic responses. Eur Respir J 4: 667–672.

    PubMed  CAS  Google Scholar 

  113. Freitag A, Watson RW, Matsos G, Eastwood C, O’Byrne PM (1993) The effect of a platelet activating factor antagonist, WEB 2086, on allergen-induced asthmatic responses. Thorax 48: 594–598.

    PubMed  CAS  Google Scholar 

  114. Kuitert LM, Angus RM, Barnes NC, Barnes PJ, Bone MF, Chung KF, Fairfax Ai, Higenbotham TW, O’Connor BJ, Piotrowska B, et al. (1994) Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. Am J Respir Crit Care Med 149: 1142–1148.

    Google Scholar 

  115. Gardiner PV, Young CL, Holmes K, Hendrick DJ, Walters EH (1993) Lack of short-term effect of the thromboxane synthetase inhibitor UK-38,485 on airway reactivity to methacholine in asthmatic subjects. Eur Respir J 6: 1027–1030.

    PubMed  CAS  Google Scholar 

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Authors
  1. Paul M. O’Byrne MB, FRCPI, FRCP(C), FCCP
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Editors and Affiliations

  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Judah A. Denburg MD, FRCP(C)

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© 1998 Springer Science+Business Media New York

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O’Byrne, P.M. (1998). Pathogenesis of Asthma. In: Denburg, J.A. (eds) Allergy and Allergic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2776-0_26

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  • DOI: https://doi.org/10.1007/978-1-4757-2776-0_26

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-026-7

  • Online ISBN: 978-1-4757-2776-0

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