Signaling in Human Basophils

  • Donald MacGlashanJr.
Chapter

Abstract

Allergic diseases occur when immunoglobulin E (IgE) antibodies, bound to specific high-affinity receptors on mast cells and basophils, are aggregated by specific antigens to induce the release of mediators, such as histamine, from these two cell types. In a search for new therapies to inhibit this allergic response, it is reasonable to explore the possibility of shutting off mediator release with an agent that interferes with the biochemical reactions that occur in these cells after aggregation occurs. Signal transduction is a general descriptive term for these biochemical events and refers to the fact that the extracellular signal, antigen binding to cell surface IgE in this case, is transduced into a cascade of biochemical changes that ultimately cause the cell to secrete preformed granules and synthesize new lipids or proteins. The motivation for such an approach comes from spectacular past successes, although these past successes, such as glucocorticosteroids, were only appreciated as signal transduction regulators long after they had become important clinical therapies. It is expected that if the signal transduction process can be understood well enough, specific therapies that only modify mast cell or basophil behavior could be developed.

Keywords

Mast Cell Histamine Release Allergy Clin Immunol Human Basophil Signal Transduction Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Scharenbery AM, Kinet JP (1995) Early events in mast cell signal transduction. Chem Immunol 61: 72.CrossRefGoogle Scholar
  2. 2.
    Schleimer RP, MacGlashan DW Jr, Gillespie E, Lichtenstein LM (1982) Inhibition of basophil histamine release by anti-inflammatory steroids. II. Studies on the mechanism of action. J Immunol 129: 1632.Google Scholar
  3. 3.
    Schulman ES, MacGlashan DW Jr, Peters SP, Schleimer RP, Newball HH, Lichtenstein LM (1982) Human lung mast cells: purification and characterization. J Immunol 129: 2662.PubMedGoogle Scholar
  4. 4.
    Glaum MC, Jaffe JS, Gillespie DH, Raible DG, Post TJ, Wang Y, Dimity E, Schulman ES (1995) IgEdependent expression of interleukin-5 mRNA and protein in human lung: modulation by dexamethasone. Clin Immunol Immunopathol 75: 171.PubMedCrossRefGoogle Scholar
  5. 5.
    MacGlashan DW Jr, Lichtenstein LM (1980) The purification of human basophils. J Immunol 124: 2519.PubMedGoogle Scholar
  6. 6.
    Warner JA, MacGlashan DW Jr (1989) Protein kinase C (PKC) changes in human basophils. IgEmediated activation is accompanied by an increase in total PKC activity. J Immunol 142: 1669.Google Scholar
  7. 7.
    Brunner T, Heusser CH, Dahinden CA (1993) Human peripheral blood basophils primed by interleukin-3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med 177: 605.Google Scholar
  8. 8.
    Naclerio RM, Kagey SA, Lichtenstein LM, Togias AG, Iliopoulos O, Pipkorn U, Bascom R, Norman PS, Proud D (1987) Observations on nasal late phase reactions. Immunol Invest 16: 649.PubMedCrossRefGoogle Scholar
  9. 9.
    Charlesworth EN, Hood AF, Soter NA, Kagey SA, Norman PS, Lichtenstein LM (1989) Cutaneous late-phase response to allergen: Mediator release and inflammatory cell infiltration. J Clin Invest 83: 1519.Google Scholar
  10. 10.
    Olson R, Karpink MH, Shelanski S, Atkins PC, Zweiman B (1990) Skin reactivity to codeine and histamine during prolonged corticosteroid therapy. J Allergy Clin Immunol 86: 153.PubMedCrossRefGoogle Scholar
  11. 11.
    Liu MC, Hubbard WC, Proud D, Stealey BA, Galli SJ, Kagey SA, Bleecker ER, Lichtenstein LM (1991) Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. Am Rev Respir Dis 144: 51.Google Scholar
  12. 12.
    Wardlaw AJ, Dunette S, Gleich GJ, Collins JV, Kay AB (1988) Eosinophils and mast cells in bronchoalveolar lavage in mild asthma: relationship to bronchial hyperreactivity. Am Rev Resp Dis 137: 62.PubMedCrossRefGoogle Scholar
  13. 13.
    Azzawi M, Bradley B, Jeffery PK, Frew AJ, Wardlaw AJ, Knowles G, Assoufi B, Collins JV, Durham S, Kay AB (1990) Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthmatics. Am Rev Resp Dis 142: 1407.PubMedGoogle Scholar
  14. 14.
    Iliopoulos O, Baroody F, Naclerio RM, Bochner BS, Kagey-Sobotka A, Lichtenstein LM (1992) Histamine containing cells obtained from the nose hours after antigen challenge have functions and phenotypic characteristics of basophils. J Immunol 148: 2223.PubMedGoogle Scholar
  15. 15.
    Siraganian RP, Hook WA (1977) Mechanism of histamine release by formyl methionine-containing peptides. J Immunol 119: 2078.PubMedGoogle Scholar
  16. 16.
    Siraganian RP, Hook WA (1976) Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction. J Immunol 116: 639.Google Scholar
  17. 17.
    Brunner T, de Weck AL, Dahinden CA (1991) Platelet-activating factor induces mediator release by human basophils primed with IL-3, granulocyte-macrophage colony-stimulating factor, or IL-5. J Immunol 147: 237.PubMedGoogle Scholar
  18. 18.
    Columbo M, Casolaro V, Warner JA, MacGlashan DW Jr, Kagey-Sobotka A, Lichtenstein LM (1990) The mechanism of mediator release from human basophils induced by platelet-activating factor. J Immunol 145: 3855.PubMedGoogle Scholar
  19. 19.
    Bischoff SC, Krieger M, Brunner, T, Dahinden CA (1992) Monocyte chemotactic protein 1 is a potent activator of human basophils. J Exp Med 175: 1271.PubMedCrossRefGoogle Scholar
  20. 20.
    MacDonald SM, Lichtenstein LM, Proud D, Plaut M, Naclerio RM, MacGlashan DW, Kagey SA (1987) Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139: 506.PubMedGoogle Scholar
  21. 21.
    MacDonald S, Lichtenstein LM (1995) Cloning and expression of histamine releasing factor. Science 269: 688.PubMedCrossRefGoogle Scholar
  22. 22.
    O’Donnell MC, Ackerman SJ, Gleich GJ, Thomas LL (1983) Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med 157: 1981.PubMedCrossRefGoogle Scholar
  23. 23.
    Foreman JC, Lichtenstein LM (1980) Induction of histamine secretion by polycations. Biochim Biophys Acta 629: 587.PubMedCrossRefGoogle Scholar
  24. 24.
    MacDonald SM, Schleimer RP, Kagey SA, Gillis S, Lichtenstein LM (1989) Recombinant IL-3 induces histamine release from human basophils. J Immunol 142: 3527.PubMedGoogle Scholar
  25. 25.
    Warner JA, Peters SP, Lichtenstein LM, Hubbard W, Yancey KB, Stevenson HC, Miller PJ, MacGlashan DW Jr (1989) Differential release of mediators from human basophils: differences in arachidonic acid metabolism following activation by unrelated stimuli. J Leukocyte Biol 45: 558.PubMedGoogle Scholar
  26. 26.
    Warner JA, MacGlashan DW Jr (1990) Signal transduction events in human basophils-a comparative study of the role of protein kinase-C in basophils activated by anti-IgE antibody and formyl-methionylleucyl-phenylalanine J Immunol 145: 1897.Google Scholar
  27. 27.
    MacGlashan DW Jr, Warner JA (1991) Stimulus-dependent leukotriene release from human basophils: a comparative study of C5a and Fmet-leu-phe. J Leukocyte Biol 49: 29.PubMedGoogle Scholar
  28. 28.
    Warner JA, Yancey KB, MacGlashan DW Jr (1987) The effect of pertussis toxin on mediator release from human basophils. J Immunol 139: 161.PubMedGoogle Scholar
  29. 29.
    Botana LM, MacGlashan DW Jr (1991) Differential effects of cAMP on mediator release in human basophils. FASEB J 5: A1007.Google Scholar
  30. 30.
    Ali H, Cunha MJR, Saul WF, Beaven MA (1990) Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells: evidence for a novel adenosine receptor. J Biol Chem 265: 745.PubMedGoogle Scholar
  31. 31.
    Collado ED, Cunha MJR, Beaven MA (1990) Treatment with dexamethasone down-regulates IgEreceptor-mediated signals and up-regulates adenosine-receptor-mediated signals in a rat mast cell (RBL-2H3) line. J Immunol 144: 244.Google Scholar
  32. 32.
    Collado EH, Ali H, Beaven MA (1990) On the mechanism of action of dexamethasone in a rat mast cell line (RBL-2H3 cells). Evidence for altered coupling of receptors and G-proteins. J Immunol 144: 3449.Google Scholar
  33. 33.
    MacGlashan DW Jr (1993) Releasability of human basophils: Cellular sensitivity and maximal histamine release are independent variables. J Allergy Clin Immunol 91: 605.PubMedCrossRefGoogle Scholar
  34. 34.
    MacGlashan DW Jr, Botana L (1993) Biphasic Ca++ responses in human basophils: evidence that the initial transient elevation associated with mobilization of intracellular calcium is an insufficient signal for degranulation. J Immunol 150: 980.Google Scholar
  35. 35.
    MacGlashan DW Jr, Bochner B, Warner JA (1994) Graded changes in the response of individual human basophils to stimulation: Distributional behavior of early activation events. J Leukocyte Biol 55: 13.Google Scholar
  36. 36.
    MacGlashan DW Jr (1995) Graded changes in the response of individual human basophils to stimulation: distributional behavior of events temporally coincident with degranulation. J Leukocyte Biol 58: 177.PubMedGoogle Scholar
  37. 37.
    Knol EF, Mul FPJ, Jansen H, Calafat J, Roos D (1991) Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 88: 328.PubMedCrossRefGoogle Scholar
  38. 38.
    Pruzansky JJ, Zeiss CR, Patterson R (1980) A linear correlation between histamine release and degranulation of human basophils by specific antigen or the ionophore A23187. Immunology 40: 411.PubMedGoogle Scholar
  39. 39.
    Dvorak AM, Newball HH, Dvorak HF, Lichtenstein LM (1980) Antigen-induced IgE-mediated degranulation of human basophils. Lab Invest 43: 126.PubMedGoogle Scholar
  40. 40.
    Conroy MC, Adkinson NFJ, Lichtenstein LM (1977) Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release. J Immunol 118: 1317.PubMedGoogle Scholar
  41. 41.
    Malveaux FJ, Conroy MC, Adkinson NFJ, Lichtenstein LM (1978) IgE receptors on human basophils. Relationship to serum IgE concentration. J Clin Invest 62: 176.Google Scholar
  42. 42.
    Wilde C (1994) Cabo San Lucas Meeting: The Role of Basophils and Eosinophils in Human Disease.Google Scholar
  43. 43.
    Dvorak AM (1992) Basophils and mast cells: Piecemeal degranulation in situ and ex vivo: A possible mechanism for cytokine-induced function in disease. In: Coffey RG, ed. Granulocyte Responses to Cytokines, Marcel Dekker, New York, p. 169.Google Scholar
  44. 44.
    Dvorak AM, Morgan ES, Lichtenstein LM, MacGlashan DW Jr (1994) Activated human basophils contain histamine in cytoplasmic vesicles. Int Arch Allergy Immunol 105: 8.PubMedCrossRefGoogle Scholar
  45. 45.
    Dvorak AM, Warner JA, Morgan E, Kissell-Rainville S, Lichtenstein LM, MacGlashan DW Jr (1992) An ultrastructural analysis of tumor-promoting phorbol diester-induced degranulation in human basophils. Am J Pathol 141: 1309.PubMedGoogle Scholar
  46. 46.
    Dvorak AM, Warner JA, Kissell S, Lichtenstein LM, MacGlashan DW Jr (1991) F-met peptide-induced degranulation of human basophils. Lab Invest 64: 234.PubMedGoogle Scholar
  47. 47.
    Warner JA, Bochner BS, MacGlashan DW Jr (1990) Cytoskeletal rearrangement and shape change in human basophils. J Allergy Clin Immunol 146: la.Google Scholar
  48. 48.
    MacGlashan DW Jr, Peters SP, Warner J, Lichtenstein LM (1986) Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links J Immunol 136: 2231.Google Scholar
  49. 49.
    MacGlashan DW Jr, Schleimer RP, Peters SP, Schulman ES, Adams GK, Newball HH, Lichtenstein LM (1982) Generation of leukotrienes by purified human lung mast cells. J Clin Invest 70: 747.PubMedCrossRefGoogle Scholar
  50. 50.
    Lewis RA, Soter NA, Diamond PT, Austen KF, Oates JA, Roberts LJ (1982) Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J Immunol 129: 1627.PubMedGoogle Scholar
  51. 51.
    Lawrence ID, Warner JA, Cohan VL, Hubbard WC, Kagey SA, Lichtenstein LM (1987) Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. J Immunol 139: 3062.Google Scholar
  52. 52.
    Murakami M, Kudo I, Suwa Y, Inoue K (1992) Release of 14-kDa group II phospholipase A2 from activated mast cells and its possible involvement in the regulation of the degranulation process. Eur J Biochem 209: 257.PubMedCrossRefGoogle Scholar
  53. 53.
    Hundley TR, Marshall L, Hubbard WC, MacGlashan DW Jr (1998) Arachidonic acid release for leukotriene C4 synthesis in human basophils is mediated by a secretory phospholipase A2, J Pharmacol Exp Ther.Google Scholar
  54. 54.
    Schievella AR, Regier MK, Smith WL, Lin LL (1995) Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270: 30, 749.Google Scholar
  55. 55.
    Woods JW, Evans JF, Ethier D, Scott S, Vickers PJ, Hearn L, Heibein JA, Charleson S, Singer II (1993) 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 178: 1935.Google Scholar
  56. 56.
    Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, Milona N, Knoph JL (1991) A novel arachidonic acid-selective cytosolic PLA2 contains a Ca’-dependent translocation domain with homology to PKC and GAP. Cell 65: 1043.PubMedCrossRefGoogle Scholar
  57. 57.
    Roshak A, Sathe G, Marshall LA (1994) Supression of monocyte 85-kDa phospholipase A2 by anti-sense and effects on endotoxin-induced prostaglandin biosynthesis. J Biol Chem 269: 25, 999.Google Scholar
  58. 58.
    Marshall LA, Bolognese B, Roshak A (1997) Distinct phospholipase A2 enzymes differentially mediate human monocyte eicosanoid formation. J Biol Chem 272: 759.PubMedCrossRefGoogle Scholar
  59. 59.
    Marshall LA, Hall RH, Winkler JD, Bolognese B, Roshak A, Flamburg PL, Sung SM, Chabot-Fletcher M, Adams JL, Mayer RJ (1995) SB 203347, an inhibitor of 14 kDa phospholipase A2, alters neutrophil arachidonic acid release and metabolism and prolongs survival in murine edndtoxin shock. J Pharmacol Exp Therap 274: 1254.Google Scholar
  60. 60.
    MacGlashan DW Jr, Hubbard WC (1993) Interleukin-3 alters free arachidonic acid generation in C5astimulated human basophils. J Immunol 151: 6358.PubMedGoogle Scholar
  61. 61.
    Columbo M, Taglialalatela M, Warner JA, MacGlashan DW Jr, Yasumoto T, Annunziato L, Marone G (1992) Maitotoxin, a novel activator of mediator release from human basophils, induces large increases in cytosolic calcium resulting in histamine, but not leukotriene C4 release. J Pharmacol Exp Therap 263: 979.Google Scholar
  62. 62.
    MacGlashan DW Jr, White JM, Huang SK, Ono SJ, Schroeder J, Lichtenstein LM (1994) Secretion of interleukin-4 from human basophils: The relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 152: 3006.PubMedGoogle Scholar
  63. 63.
    Sim TC, Li H, Reece LM, Alam R (1996) Interleukin-13 production by human basophils. J Allergy Clin Immunol 97: 358a.Google Scholar
  64. 64.
    Li H, Sin TC, Grant JA, Alam R (1996) The production of MIP-la by basophils and its comparison to the production by other leukocytes. J Allergy Clin Immunol 97: 267a.Google Scholar
  65. 65.
    Schroeder JT, MacGlashan DW Jr, Kagey-Sobotka A, White JM, Lichtenstein LM (1994) The IgEdependent IL-4 secretion by human basophils: The relationship between cytokine production and histamine release in mixed leukocyte cultures. J Immunol 153: 1808.Google Scholar
  66. 66.
    Schroeder JT, Lichtenstein LM, Kagey-Sobotka A, MacGlashan DW Jr (1996) IL-4 secretion by human basophils and lymphocytes is differentially regulated by protein kinase C activation, submitted.Google Scholar
  67. 67.
    Baumgartner RA, Yamada K, Deramo VA, Beaven MA (1994) Secretion of TNF from a rat mast cell line is a brefeldin A-sensitive and calcium/protein kinase C-regulated process. J Immunol 153: 2609.PubMedGoogle Scholar
  68. 68.
    Jaffe JS, Glaum MC, Raible DG, Post TJ, Dimitry E, Govindarao D, Wang Y, Schulman ES (1995) Human lung mast cell IL-5 gene and protein expression: temporal analysis of upregulation following IgE-mediated activation. Am J Respir Cell Mol Biol 13: 665.PubMedGoogle Scholar
  69. 69.
    Casolaro V, Georas S, Song Z, Zubkoff ID, Abdulkadir SA, Thanos D, Ono SJ (1995) Inhibition of NFATp-dependent transcription by NFkB. Implications for differential gene expression in T cell subsets. Proc Natl Acad Sci USA 92: 11, 623.Google Scholar
  70. 70.
    Lichtenstein LM, De Bernardo R (1971) IgE mediated histamine release: in vitro separation into two phases. Int Arch Allergy Appl Immunol 41: 56.PubMedCrossRefGoogle Scholar
  71. 71.
    Sobotka AK, Dembo M, Goldstein B, Lichtenstein LM (1979) Antigen-specific desensitization of human basophils. J Immunol 122: 511.PubMedGoogle Scholar
  72. 72.
    Dembo M, Goldstein B (1980) A model of cell activation and desensitization by surface immunoglobin: the case of histamine release from human basophils. Cell 22: 59.PubMedCrossRefGoogle Scholar
  73. 73.
    Kazimierczak W, Mier HL, MacGlashan DW Jr, Lichtenstein LM (1984) An antigen-activated DFPinhibitable enzyme controls basophil desensitization. J Immunol 132: 399.PubMedGoogle Scholar
  74. 74.
    Blank U, Ra C, Miller L, White K, Metzger H, Kinet JP (1989) Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 337: 187.PubMedCrossRefGoogle Scholar
  75. 75.
    Benhamou M, Gutkind JS, Robbins KC, Siraganian RP (1990) Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci USA 87: 5327.PubMedCrossRefGoogle Scholar
  76. 76.
    Benhamou M, Stephan V, Gutkind SJ, Robbins KC, Siraganian RP (1991) Protein tyrosine phosphorylation in the degranulation step of RBL-2H3 cells. FASEB J 5: A1007.Google Scholar
  77. 77.
    Stephan V, Benhamou M, Gutkind JS, Robbins KC, Siraganian RP (1992) Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. J Biol Chem 267: 5434.Google Scholar
  78. 78.
    Paolini R, Jouvin MH, Kinet JP (1991) Phosphorylation and dephosphorylation of the high affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement. Nature 353: 855.Google Scholar
  79. 79.
    Yamashita T, Mao SY, Metzger H (1994) Aggregation of the high-affinity IgE receptor and enhanced activity of p53/561yn protein-tyrosine kinase. Proc Natl Acad Sci USA 91: 11, 251.Google Scholar
  80. 80.
    Eiseman E, Bolen JB (1992) Signal transduction by the cytoplasmic domains of Fc epsilon RI-gamma and TCR-zeta in rat basophilic leukemia cells. J Biol Chem 267: 21, 027.Google Scholar
  81. 81.
    Jouvin MH, Adamczewski M, Numerof R, Letourneur O, Valle A, Kinet JP (1994) Differential control of the tyrosine kinase lyn and syk by the two signaling chains of the high affinity immunoglobulin E receptor. J Biol Chem 269: 5918.Google Scholar
  82. 82.
    Eiseman E, Bolen JB (1992) Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355: 78.PubMedCrossRefGoogle Scholar
  83. 83.
    Kihara H, Siraganian RP (1994) Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J Biol Chem 269: 22, 427.Google Scholar
  84. 84.
    Scharenberg AM, Lin S, Cuenod B, Yamamura H, Kinet JP (1995) Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering. EMBO J 14: 3385.PubMedGoogle Scholar
  85. 85.
    Cambier JC (1995) Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM) (review). J Immunol 155: 3281.PubMedGoogle Scholar
  86. 86.
    Hutchcroft JE, Geahlen RL, Deanin GG, Oliver JM (1992) Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci USA 89: 9107.Google Scholar
  87. 87.
    Li W, Deanin GG, Margolis B, Schlessinger J, Oliver JM (1992) FceRI-mediated tyrosine phosphorylation of multiple proteins including phospholipase C gamma 1 and the receptor beta/gamma2 complex in RBL-2H3 cells. Mol Cell Biol 12: 3176.PubMedGoogle Scholar
  88. 88.
    Shiue L, Zoller MJ, Brugge JS (1995) Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affmity receptor for IgE. J Biol Chem 270: 10, 498.Google Scholar
  89. 89.
    Hirasawa N, Scharenberg A, Yamamura H, Beaven MA, Kinet JP (1995) A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by Fc epsilon R1 is not shared by a G protein-coupled receptor. J Biol Chem 270: 10, 960.Google Scholar
  90. 90.
    Lin LL, Wartmann M, Lin A, Knoph JL, Seth A, Davis RJ (1993) cPLA2 is phosphorylated and activated by MAP kinase. Cell 72: 269.Google Scholar
  91. 91.
    Ludowyke RI, Peleg I, Beaven MA, Adelstein RS (1989) Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in RBL cells. J Biol Chem 264: 12, 492.Google Scholar
  92. 92.
    Choi OH, Adelstein RS, Beaven MA (1994) Secretion from RBL-2H3 cells is associated with phosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J Biol Chem 269: 536.PubMedGoogle Scholar
  93. 93.
    Hamawy MM, Mergenhagen SE, Siraganian RP (1993) Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptor requires adherence. J Biol Chem 268: 6851.Google Scholar
  94. 94.
    Beaven MA, Guthrie DF, Moore JP, Smith GA, Hesketh TR, Metcalfe JC (1987) Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. J Cell Biol 105: 1129.PubMedCrossRefGoogle Scholar
  95. 95.
    Choi OH, Kim JH, Kinet JP (1996) Calcium mobilization via sphingosine kinase in signaling by the FceRI antigen receptor. Nature 380: 634.PubMedCrossRefGoogle Scholar
  96. 96.
    Ozawa K, Szallasi Z, Kanzanietz MG, Blumberg PM, Mischak H, Mushinski JF, Beaven MA (1993) Cat+-dependent and Ca’-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells: reconstitution of secretory responses with Cat* and purified isozymes in washed permeabilized cells. J Biol Chem 268: 1749.PubMedGoogle Scholar
  97. 97.
    Ozawa K, Yamada K, Kanzanietz MG, Blumberg PM, Beaven MA (1993) Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells. J Biol Chem 268: 2280.PubMedGoogle Scholar
  98. 98.
    Dekker LV, Parker PJ (1994) Protein kinase C: a question of specificity. Trends Biochem Sci 19: 73.PubMedCrossRefGoogle Scholar
  99. 99.
    Schleimer RP, Gillespie E, Lichtenstein LM (1981) Release of histamine from human leukocytes stimulated with the tumor promoting phorbol esters. I. Characterization of the response. J Immunol 126: 570.Google Scholar
  100. 100.
    Tamaoki T, Takahashi I, Kobayashi E, Nakano H, Akinaga S, Suzuki K (1990) Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C. Adv Second Messenger Phosphoprotein Res 24: 497.PubMedGoogle Scholar
  101. 101.
    Devalia V, Thomas SB, Roberts PJ, Jones M, Linch (1992) Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation. Blood 80: 68.Google Scholar
  102. 102.
    Dang PM, Rais S, Hakim J, Perianin A (1995) Redistribution of protein kinase C isoforms in human neutrophils stimulated by formyl peptides and phorbol myristate acetate. Biochem Biophys Res Comm 212: 664.PubMedCrossRefGoogle Scholar
  103. 103.
    Bates ME, Bertics PJ, Calhoun WJ, Busse WW (1993) Increased protein kinase C activity in low density eosinophils. J Immunol 150: 4486.PubMedGoogle Scholar
  104. 104.
    Lavens SE, Peachell PT, Warner JA (1992) Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils. Am J Respir Cell Mol Biol 7: 637.PubMedGoogle Scholar
  105. 105.
    Lavens SE, Warner JA (1995) The role of the tyrosine kinase, SYK, in IgE-mediated signal transduction in human lung mast cells and basophils. FASEB J 9: A781.Google Scholar
  106. 106.
    Berger SA, Mak TW, Paige CJ (1994) Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells. J Exp Med 180: 471.PubMedCrossRefGoogle Scholar
  107. 107.
    Hook WA, Berenstein EH, Zinsser FU, Fishier C, Siraganian RP (1991) Monoclonal antibodies to the leukocyte common antigen (CD45) inhibit IgE-mediated histamine release from human basophils. J Immunol 147: 2670.PubMedGoogle Scholar
  108. 108.
    Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA (1995) Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med 181: 2077.PubMedCrossRefGoogle Scholar
  109. 109.
    Nguyen KL, Gillis S, MacGlashan DW Jr (1990) A comparative study of releasing and nonreleasing human basophils: nonreleasing basophils lack an early component of the signal transduction pathway that follows IgE cross-linking. J Allergy Clin Immunol 85: 1020.PubMedCrossRefGoogle Scholar
  110. 110.
    Yamaguchi M, Hirai K, Ohta K, Suzuki K, Kitani S, Takaishi T, Ito K, Ra C, Morita Y (1996) Culturing in the presence of IL-3 converts anti-IgE nonresponding basophils into responding basophils. J Allergy Clin Immunol 97: 1279.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Donald MacGlashanJr.

There are no affiliations available

Personalised recommendations