Signaling in Human Basophils

  • Donald MacGlashanJr.


Allergic diseases occur when immunoglobulin E (IgE) antibodies, bound to specific high-affinity receptors on mast cells and basophils, are aggregated by specific antigens to induce the release of mediators, such as histamine, from these two cell types. In a search for new therapies to inhibit this allergic response, it is reasonable to explore the possibility of shutting off mediator release with an agent that interferes with the biochemical reactions that occur in these cells after aggregation occurs. Signal transduction is a general descriptive term for these biochemical events and refers to the fact that the extracellular signal, antigen binding to cell surface IgE in this case, is transduced into a cascade of biochemical changes that ultimately cause the cell to secrete preformed granules and synthesize new lipids or proteins. The motivation for such an approach comes from spectacular past successes, although these past successes, such as glucocorticosteroids, were only appreciated as signal transduction regulators long after they had become important clinical therapies. It is expected that if the signal transduction process can be understood well enough, specific therapies that only modify mast cell or basophil behavior could be developed.


Mast Cell Histamine Release Allergy Clin Immunol Human Basophil Signal Transduction Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  • Donald MacGlashanJr.

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