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Cytokines and IgE Regulation

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Allergy and Allergic Diseases

Abstract

Synthesis of allergen-specific immunoglobulin E (IgE) in vivo is a result of multiple interactions among B-cells, T-cells, and professional antigen-presenting cells (APC). B-cell activation is initiated when specific B-cells recognize the allergen by cell surface immunoglobulin (sIg). However, costimulatory molecules expressed by activated T cells in both soluble and membrane-bound forms are necessary for differentiation of B-cells into Ig-secreting plasma cells (1). Activation of T helper (Th) cells requires recognition of an antigenic peptide in the context of major histocompatibility complex (MHC) class II molecules on the plasma membrane of APC, such as monocytes, dendritic cells, Langerhans cells, or primed B-cells. Professional APC can efficiently capture the antigen, and the peptide-MHC class II complexes are formed in a post-Golgi, proteolytic intracellular compartment and subsequently exported to the plasma membrane, where they are recognized by T-cell receptor (TCR) (2). In addition, activated B-cells express CD80 (B7-1) and CD86 (B7-2, B70), which are the counter receptors for CD28 and which provide a costimulatory signal for T-cell activation resulting in T-cell proliferation and cytokine synthesis (3). Since allergen-specific T-cells from atopic individuals generally belong to the Th2-cell subset, activation of these cells also leads to production of interleukin (IL)-4 and IL-13, which, together with membrane-bound costimulatory molecules expressed by activated T-helper cells, direct B-cell differentiation into IgE-secreting plasma cells.

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Authors
  1. Juha Punnonen MD, PhD
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  2. Jan E. de Vries PhD
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Editors and Affiliations

  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Judah A. Denburg MD, FRCP(C)

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Punnonen, J., de Vries, J.E. (1998). Cytokines and IgE Regulation. In: Denburg, J.A. (eds) Allergy and Allergic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2776-0_2

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  • DOI: https://doi.org/10.1007/978-1-4757-2776-0_2

  • Publisher Name: Humana Press, Totowa, NJ

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