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Epithelium

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Allergy and Allergic Diseases

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Abstract

The epithelium is the critical cell layer at mucosal surfaces since it forms the boundary between the external environment and the body proper. This cell layer plays a major role in host defense since it serves as a barrier and secretes fluid, mucus, and antibodies that contribute to the elimination of antigens from the body. Over the past 15 y, many experimental studies have been published that provide insights into the role of epithelial cells in allergic diseases. It is now recognized that the functions of epithelia are regulated by nerves and altered by immune cell mediators and cytokines. New evidence suggests that stress increases epithelial permeability. Enhanced transepithelial uptake of antigens, infectious agents, and toxins may stimulate allergic reactions and/or inflammatory responses that cause epithelial injury.

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Authors
  1. Mary H. Perdue PhD
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  2. Derek M. McKay PhD
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Editors and Affiliations

  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Judah A. Denburg MD, FRCP(C)

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Perdue, M.H., McKay, D.M. (1998). Epithelium. In: Denburg, J.A. (eds) Allergy and Allergic Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2776-0_15

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  • DOI: https://doi.org/10.1007/978-1-4757-2776-0_15

  • Publisher Name: Humana Press, Totowa, NJ

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