Role of CD8+ T-Cells in the Regulation of Immunoglobulin E

  • Paul A. MacAry
  • David M. Kemeny


Asthma and other allergic diseases have become increasingly common in the latter part of the 20th century. Allergic reactions in the airways are triggered by immunoglobulin E (IgE) sensitized mast cells and T-helper 2 (Th2) CD4+ T-cells, whose activation leads to the infiltration of other inflammatory cells, which contribute to tissue damage. One-third of all circulating T-cells are CD8+/CD4. These cells are found at all immune sites and are particularly prominent in mucosal tissues, where they provide a first line of defense fulfilling an immunological gatekeeper function (1,2). CD8+ T-cells recognize intracellular antigens presented via major histocompatibility complex (MHC) class I and are more cytolytic than CD4+ T-cells, producing perforin and degradative enzymes such as granzyme B. CD8+ T-cells can kill MHC class-I peptide-bearing target cells via the Fas-dependent “kiss-of-death” pathway. In this chapter we will review the role of CD8+ T-cells in IgE regulation.


Major Histocompatibility Complex Major Histocompatibility Complex Class Castor Bean Tuberculoid Leprosy Sensitize Mast Cell 
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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Paul A. MacAry
  • David M. Kemeny

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