Th1/Th2 Cells
  • Sergio Romagnani


Atopic allergy is a genetically determined disorder characterized by an increased ability of B-lymphocytes to form immunoglobulin E (IgE) antibodies to certain groups of ubiquitous antigens that can activate the immune system after inhalation or ingestion, and perhaps after penetration through the skin (allergens). IgE antibodies are able to bind to high-affinity (type I) Fce receptors (FcεRI) present on the surface of mast cells/basophils, and allergen-induced FcεRI cross linking triggers the release of vasoactive mediators, chemotactic factors, and cytokines that are responsible for the allergic cascade. In addition to IgE-producing B-cells and IgE-binding mast cells/basophils, eosinophils also appear to be involved in the pathogenesis of allergic reactions, since these cells usually accumulate in the sites of allergic inflammation and the toxic products they release significantly contribute to the induction of tissue damage. The mechanisms accounting for the joint involvement of IgE-producing B-cells, mast cells/basophils, and eosinophils in the pathogenesis of allergic reactions had remained unclear until the existence of two polarized forms of the cluster differentiation (CD)4+ T-helper (Th) cell-mediated specific immune response, based on their profile of cytokine production and defined as type 1 T-helper (Thl) and type 2 T-helper (Th2), was discovered (1).


Atopic Dermatitis Allergy Clin Immunol Atopic Dermatitis Patient Atopic Subject Vernal Conjunctivitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Sergio Romagnani

There are no affiliations available

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