Arsenic metabolism in aquatic ecosystems

  • John S. Edmonds
  • Kevin A. Francesconi


The concentration of arsenic is higher in marine organisms (Tables 6.1 and 6.2) than in freshwater organisms (Cullen and Reimer, 1989) and therefore arsenic in the sea and in marine organisms has received much greater attention than arsenic in freshwater environments; higher concentrations generally mean greater ease of study and greater fears of toxicity to be stilled. The contents of this chapter dealing with marine and freshwater environments will reflect this disproportionate attention.


Marine Alga Teleost Fish Arsenic Species Marine Animal Glycine Betaine 
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  1. Andreae, M.O. (1977) Determination of arsenic species in natural waters. Anal. Chem. 49, 820–823.CrossRefGoogle Scholar
  2. Andreae, M.O. (1978) Distribution and speciation of arsenic in natural waters and some marine algae. Deep-Sea Res. 25, 391–402.CrossRefGoogle Scholar
  3. Andreae, M.O. (1979) Arsenic speciation in seawater and interstitial waters: the influence of biological-chemical interactions on the chemistry of a trace element. Limn. Oceanog. 24, 440–452.CrossRefGoogle Scholar
  4. Andreae, M.O. and Klumpp, D. (1979) Biosynthesis and release of organo-arsenic compounds by marine algae. Environ. Sci. Technol. 13, 738–741.CrossRefGoogle Scholar
  5. Anonymous (1977) Medical and Biological Effects of Environmental Pollutants: Arsenic, National Academy of Sciences, Washington, DC.Google Scholar
  6. Armstrong, F.A.J, and Harvey, H.W. (1950) The cycle of phosphorus in the waters of the English Channel. J. Mar. Biol. Assoc. UK 29, 145–162.CrossRefGoogle Scholar
  7. Asano, M. and Itoh, M. (1960) Salivary poison of a marine gastropod Neptunea arthritica (Bernardi), and the seasonal variation of its toxicity. Ann. NY Acad. Sci. 90, 674–688.CrossRefGoogle Scholar
  8. Bebbington, G.N., Mackay, N.J., Chvojka, R. et al. (1977) Heavy metals, selenium and arsenic in nine species of Australian commercial fish. Aust. J. Mar. Freshw. Res. 28, 277–286.CrossRefGoogle Scholar
  9. Bettencourt, A.M.M. de and Andreae, M.O. (1991) Refractory arsenic species in estu-arine waters. Appl. Organometal. Chem. 5, 111–116.CrossRefGoogle Scholar
  10. Braman, R.S. and Foreback, C.C. (1973) Methylated forms of arsenic in the environment. Science 182, 1247–1249.CrossRefGoogle Scholar
  11. Byrne, A.R., Slejkovec, Z., Stijve, K. et al. (1995) Arsenobetaine and other arsenic species in mushrooms. Appl. Organometal. Chem. 9, 305–313.CrossRefGoogle Scholar
  12. Cannon, J.R., Edmonds, J.S., Francesconi, K.A. et al. (1981) Isolation, crystal structure and synthesis of arsenobetaine, a constituent of the western rock lobster, Panulirus cygnus, the dusky shark, Carcharhinus obscurus, and some samples of human urine. Aust. J. Chem. 34, 787–798.CrossRefGoogle Scholar
  13. Cantoni, G.L. (1952) The nature of the active methyl donor formed enzymatically from L-methionine and adenosinetriphosphate. J. Am. Chem. Soc. 74, 2942–2943.CrossRefGoogle Scholar
  14. Challenger, F. (1945) Biological methylation. Chem. Revs 36, 315–361.CrossRefGoogle Scholar
  15. Challenger, F. (1951) Biological methylation. Adv. Enzymol. 12, 429–491.Google Scholar
  16. Challenger, F., Higginbottom, C. and Ellis, L. (1933) The formation of organo-met-alloid compounds by microorganisms. Part 1. Trimethylarsine and dimethyl-ethylarsine. J. Chem. Soc. 95–101.Google Scholar
  17. Cooney, R.V. and Benson, A.A. (1980) Arsenic metabolism in Homarus americanus. Chemosphere 9, 335–341.CrossRefGoogle Scholar
  18. Cullen, W.R. and Dodd, M. (1989) Arsenic speciation in clams of British Columbia. Appl. Organometal. Chem. 3, 79–88.CrossRefGoogle Scholar
  19. Cullen, W.R. and Reimer, K.J. (1989) Arsenic speciation in the environment. Chem. Revs 89, 713–764.CrossRefGoogle Scholar
  20. Cullen, W.R., Harrison, L.G., Li, H. and Hewitt, G. (1994) Bioaccumulation and excretion of arsenic compounds by a marine unicellular alga, Polyphysa penicu-lus.Appl. Organometal. Chem. 8, 313–324.CrossRefGoogle Scholar
  21. Dhandhukia, M.M. and Seshadri, K. (1969) Arsenic content in marine algae. Phykos 8, 108–111.Google Scholar
  22. Edmonds, J.S. and Francesconi, K.A. (1981) Arseno-sugars from brown kelp (Ecklo-nia radiata) as intermediates in cycling of arsenic in a marine ecosystem. Nature 289, 602–604.CrossRefGoogle Scholar
  23. Edmonds, J.S. and Francesconi, K.A. (1983) Arsenic-containing ribofuranosides: isolation from brown kelp Ecklonia radiata and NMR spectra. J. Chem. Soc, Perkin Transactions 1, 2375–2382.CrossRefGoogle Scholar
  24. Edmonds, J.S. and Francesconi, K.A. (1987a) Transformations of arsenic in the marine environment. Experientia 43, 553–557.CrossRefGoogle Scholar
  25. Edmonds, J.S. and Francesconi, K.A. (1987b) Trimethylarsine oxide in estuary catfish (Cnidoglanis macrocephalus) and school whiting (Sillago bassensis) after oral administration of sodium arsenate; and as a natural component of estuary catfish. Sei. Total Environ. 64, 317–323.CrossRefGoogle Scholar
  26. Edmonds, J.S. and Francesconi, K.A. (1988) The origin of arsenobetaine in marine animals. Appl. Organometal. Chem. 2, 297–302.CrossRefGoogle Scholar
  27. Edmonds, J.S., Francesconi, K.A., Cannon, J.R. et al. (1977) Isolation, crystal structure and synthesis of arsenobetaine, the arsenical constituent of the western rock lobster Panulirus longipes cygnus (George). Tetrahedron Letts 18, 1543–1546.CrossRefGoogle Scholar
  28. Edmonds, J.S., Francesconi, K.A. and Hansen, J.A. (1982) Dimethyloxarsylethanol from anaerobic decomposition of brown kelp Ecklonia radiata: a likely precursor of arsenobetaine in marine fauna. Experientia 38, 643–644.CrossRefGoogle Scholar
  29. Edmonds, J.S., Shibata, Y., Francesconi, K.A. et al. (1992) Arsenic lipids in the digestive gland of the western rock lobster Panulirus cygnus: an investigation by HPLC ICP-MS. Sei. Total Environ. 122, 321–335.CrossRefGoogle Scholar
  30. Edmonds, J.S., Francesconi, K.A. and Stick, R.V. (1993) Arsenic compounds from marine organisms. Nat. Prod. Reps 10, 421–428.CrossRefGoogle Scholar
  31. Egaas, E. and Braekkan, O.R. (1977) The arsenic content of some Norwegian fish products. Fiskeridirektoratets Skrifler Serie Ernœring 1, 93–98.Google Scholar
  32. Falconer, CR., Shepherd, R.J., Pirie, J.M. and Topping, G. (1983) Arsenic levels in fish and shellfish from the North sea. J. Exper. Mar. Biol Ecol. 71, 193–203.CrossRefGoogle Scholar
  33. Fänge, R. (1960) The salivary gland of Neptunea antiqua. Anns NY Acad. Sci. 90, 689–694.CrossRefGoogle Scholar
  34. Francesconi, K.A. and Edmonds, J.S. (1987) Accumulation of arsenobetaine from seawater by the mussel (Mytilus edulis), in Heavy Metals in the Environment, Vol. 2, (eds S.E. Lindberg and T.C. Hutchinson), CEP Consultants, Edinburgh, pp. 71–73.Google Scholar
  35. Francesconi, K.A. and Edmonds, J.S. (1993) Arsenic in the sea. Oceanog. Mar. Biol. Ann. Rev. 31, 111–151.Google Scholar
  36. Francesconi, K.A. and Edmonds, J.S. (in press) Arsenic and marine organisms. Adv. Inorg. Chem. Google Scholar
  37. Francesconi, K.A., Edmonds, J.S. and Hatcher, B.G. (1988) Examination of the arsenic constituents of the herbivorous marine gastropod Tectus pyramis: isolation of tetramethylarsonium ion. Comp. Biochem. Physiol. 90C, 313–316.Google Scholar
  38. Francesconi, K.A., Edmonds, J.S. and Stick, R.V. (1989) Accumulation of arsenic in yelloweye mullet (Aldrichetta forsteri) following oral administration of organoarsenic compounds and arsenate. Sei. Total Environ. 79, 59–67.CrossRefGoogle Scholar
  39. Francesconi, K.A., Stick, R.V. and Edmonds J.S. (1990) Glycerylphosphorylarseno-choline and phosphatidylarsenocholine in yelloweye mullet (Aldrichetta forsteri) following oral administration of arsenocholine. Experientia 46, 464–466.CrossRefGoogle Scholar
  40. Francesconi, K.A., Edmonds, J.S., Stick, R.V. et al. (1991a) Arsenic-containing ribosides from the brown alga Sargassum lacerifolium: X-ray molecular structure of amino-3-[5′-deoxy-5′-(dimethylarsinoyl)ribosyloxy]propane-l-sulphonic acid. J. Chem. Soc, Perkin Transactions 1, 2707–2716.CrossRefGoogle Scholar
  41. Francesconi, K.A., Stick, R.V. and Edmonds, J.S. (1991b) An arsenic-containing nucleoside from the kidney of the giant clam, Tridacna maxima. J. Chem. Soc, Chem. Commun. 928–929.Google Scholar
  42. Francesconi, K.A., Edmonds, J.S. and Stick, R.V. (1992a) Arsenic compounds from the kidney of the giant clam Tridacna maxima: Isolation and identification of an arsenic-containing nucleoside. J. Chem. Soc, Perkin Transactions 1, 1349–1357.CrossRefGoogle Scholar
  43. Francesconi, K.A., Edmonds, J.S. and Stick, R.V. (1992b) Arsenocholine from anaerobic decomposition of a trimethylarsonioriboside. Appl. Organometal. Chem. 6, 247–249.CrossRefGoogle Scholar
  44. Francesconi, K.A., Edmonds, J.S. and Stick, R.V. (1994) Synthesis, NMR spectra and chromatographic properties of five trimethylarsonioribosides. Appl. Organometal. Chem. 8,517–523.CrossRefGoogle Scholar
  45. Gailer, J., Francesconi, K.A., Edmonds, J.S. and Irgolic, K.J. (1995) Metabolism of arsenic compounds by the blue mussel Mytilus edulis after accumulation from seawater spiked with arsenic compounds. Appl. Organometal. Chem. 9, 341–355.CrossRefGoogle Scholar
  46. Glover, J.W. (1979) Concentrations of arsenic, selenium and ten heavy metals in school shark, Galeorhinus australis (Macleay) and gummy shark, Mustelus antarcticus (Günther), from south-eastern Australian waters. Aust. J. Mar. Freshwater Res. 30, 505–510.CrossRefGoogle Scholar
  47. Gohda, S. (1975) Valence states of arsenic and antimony in sea water. Bull. Chem. Soc. Jap. 48, 1213–1216.CrossRefGoogle Scholar
  48. Gschwend P.M., MacFarlane, J.K and Newman, K.A. (1985) Volatile halogenated organic compounds released into seawater from temperate marine macroalgae. Science 111, 1033–1035.CrossRefGoogle Scholar
  49. Hall, R.A., Zook, E.G. and Meaburn, G.M. (1978) National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource, NOAA Technical Report NMFS SSRF-721, 313pp.Google Scholar
  50. Hanaoka, K., Tagawa, S. and Kaise, T. (1992) The fate of organoarsenic compounds in marine ecosystems. Appl. Organometal. Chem. 6, 139–146.CrossRefGoogle Scholar
  51. Howard, A.G. and Comber, S.D.W. (1989) The discovery of hidden arsenic species in coastal waters. Appl. Organometal. Chem. 3, 509–514.CrossRefGoogle Scholar
  52. Ishida, Y. and Kadota, H. (1967) Isolation and identification of dimethyl-ß-propio-thetin from Gyrodinium cohnii. Agric. Biol. Chem. 31, 756–757.CrossRefGoogle Scholar
  53. Jin, K., Hayashi, T., Shibata, Y. and Morita, M. (1988) Arsenic-containing ribofura-nosides and dimethylarsinic acid in green seaweed, Codium fragile. Appl. Organometal. Chem. 2, 365–369.CrossRefGoogle Scholar
  54. Johnson, D.L. (1972) Bacterial reduction of arsenate in sea water. Nature 240, 44–45.CrossRefGoogle Scholar
  55. Johnson, D.L. and Burke, R.M. (1978) Biological mediation of chemical speciation. II. Arsenate reduction during marine phytoplankton blooms. Chemosphere 7, 645–648.CrossRefGoogle Scholar
  56. Johnson, D.L. and Pilson, M.E.Q. (1972) Arsenate in the western North Atlantic and adjacent regions. J. Mar. Res. 30, 140–149.Google Scholar
  57. Kennedy, V.S. (1976) Arsenic concentrations in some coexisting marine organisms from Newfoundland and Labrador. J. Fish. Res. Board Can. 33, 1388–1393.CrossRefGoogle Scholar
  58. Klumpp, D.W. (1980) Characteristics of arsenic accumulation by the seaweeds Fucus spiralis and Ascophyllum nodosum. Mar. Biol. 58, 257–264.CrossRefGoogle Scholar
  59. Kurosawa, S., Yasuda, K., Taguchi, N. et al. (1980) Identification of arsenobetaine, a water soluble organo-arsenic compound in muscle and liver of a shark, Prionace glaucus. Agric. Biol. Chem. 44, 1993–1994.CrossRefGoogle Scholar
  60. Lancaster, R.J., Coup, M.R. and Hughes, J.W. (1971) Toxicity of arsenic present in lakeweed. NZ Vet. J. 19, 141–145.Google Scholar
  61. Larsen, E.H., Pritzel, G. and Hansen, S.H. (1993) Speciation of eight arsenic compounds in human urine by high-performance liquid chromatography with inductively coupled plasma mass spectrometric detection using antimonate for internal chromatographic standardization. J. Anal. Atom. Spectr. 8, 557–563.CrossRefGoogle Scholar
  62. Lawrence, J.F., Michalik, P., Tarn, G. and Conacher, H.B.S. (1986) Identification of arsenobetaine and arsenocholine in Canadian fish and shellfish by high-performance liquid chromatography with atomic absorption detection and confirmation by fast atom bombardment mass spectrometry. J. Agric. Food Chem. 34, 315–319.CrossRefGoogle Scholar
  63. Leatherland, T.M. and Burton, J.D. (1974). The occurrence of some trace metals in coastal organisms with particular reference to the Solent region. J. Mar. Biol. Assoc. UK 54, 457–468.CrossRefGoogle Scholar
  64. Lovelock, J.E. (1975) Natural halocarbons in the air and in the sea. Nature 256, 193–194.CrossRefGoogle Scholar
  65. Lunde, G. (1970) Analysis of arsenic and selenium in marine raw materials. J Sci. Food Agric. 21, 242–247.CrossRefGoogle Scholar
  66. Luten, J.B., Riekwel-Booy, G. and Rauchbaar, A. (1982) Occurrence of arsenic in plaice (Pleuronectes platessa), nature of organo-arsenic compound present and its excretion by man. Environ. Health Persp. 45, 165–170.CrossRefGoogle Scholar
  67. Maher, W.A. and Clarke, S.M. (1984) The occurrence of arsenic in selected marine macroalgae from two coastal areas of South Australia. Mar. Polin Bull. 15, 111–112.CrossRefGoogle Scholar
  68. McBride, B.C. and Wolfe, R.S. (1971) Biosynthesis of dimethylarsine by methanobacterium. Biochemistry 10, 4312–4317.CrossRefGoogle Scholar
  69. Maeda, S. (1994) Biotransformation of arsenic in the freshwater environment, in Arsenic in the Environment. Part 1: Cycling and Characterization, (ed. J.O. Nriagu), John Wiley & Sons, New York, pp. 155–187.Google Scholar
  70. Maugh, T.H. II (1979) It isn’t easy being king. Science 203, 637.CrossRefGoogle Scholar
  71. Morita, M. and Edmonds, J.S. (1992) Determination of arsenic species in environmental and biological samples. Pure Appl. Chem. 64, 575–590.CrossRefGoogle Scholar
  72. Morita, M. and Shibata, Y. (1987) Speciation of arsenic compounds in marine life by high performance liquid chromatography combined with inductively coupled argon plasma atomic emission spectrometry. Anal. Sci. 3, 575–577.CrossRefGoogle Scholar
  73. Morita, M. and Shibata, Y. (1988) Isolation and identification of arseno-lipid from a brown alga, Undaria pinnatifida (Wakame). Chemosphere 17, 1147–1152.CrossRefGoogle Scholar
  74. Morita, M. and Shibata, Y. (1990) Chemical form of arsenic in marine macroalgae. Appl. Organometal. Chem. 4, 181–190.CrossRefGoogle Scholar
  75. Noguchi, K. and Nakagawa, R. (1970) Arsenic in the waters and deposits of Osoreyama hot springs, Aomori Prefecture. Nippon Kagaku Zasshi 91, 127–131.CrossRefGoogle Scholar
  76. Norin, H., Ryhage, R., Christakopoulos, A. and Sandström, M. (1983) New evidence for the presence of arsenocholine in shrimps (Pandalus borealis) by use of pyrolysis gas chromatography-atomic absorptionjmass spectrometry. Chemosphere 12, 299–315.CrossRefGoogle Scholar
  77. Peden, J.D., Crothers, J.H., Waterfall, CE. and Beasley, J. (1973) Heavy metals in Somerset marine organisms. Mar. Polin Bull. 4, 7–9.CrossRefGoogle Scholar
  78. Phillips, D.J.H. and Depledge, M.H. (1985) Metabolic pathways involving arsenic in marine organisms: a unifying hypothesis. Mar. Environ. Res. 17, 1–12.CrossRefGoogle Scholar
  79. Portmann, J.E. and Riley, J.P. (1964) Determination of arsenic in sea water, marine plants and silicate and carbonate sediments. Anal. Chim. Acta 31, 509–519.CrossRefGoogle Scholar
  80. Powell, J.H., Powell, R.E. and Fielder, D.R. (1981) Trace element concentrations in tropical marine fish at Bougainville Island, Papua New Guinea. Water Air Soil Polin 16, 143–158.CrossRefGoogle Scholar
  81. Rao, Ch.K., Chinnaraj, S., Inamdar, S.N. and Untawale, A.G. (1991) Arsenic content in certain marine brown algae and mangroves from Goa coast. Indian J. Mar. Sci. 20, 283–285.Google Scholar
  82. Robinson, B.H., Brooks, R.R., Outred, H.A. and Kirkman, J.H. (1995) Mercury and arsenic in trout from the Taupo Volcanic Zone and Waikato River, North Island, New Zealand. Chem. Speciation Bioavail. 7, 27–32.Google Scholar
  83. Sanders, J.G. (1979) Microbial role in the demethylation and oxidation of methylated arsenicals in seawater. Chemosphere 3, 135–137.CrossRefGoogle Scholar
  84. Sanders, J.G. and Cibik, S.J. (1985) Adaptive behaviour of euryhaline phytoplankton communities to arsenic stress. Mar. Ecol. Prog. Ser. 22, 199–205.CrossRefGoogle Scholar
  85. Sanders, J.G. and Windom, H.L. (1980) The uptake and reduction of arsenic species by marine algae. Estuar. Coastal Mar. Sci. 10, 555–557.CrossRefGoogle Scholar
  86. Shibata, Y. and Morita M. (1988) A novel, trimethylated arseno-sugar isolated from the brown alga Sargassum thunbergii. Agric. Biol. Chem. 52, 1087–1089.CrossRefGoogle Scholar
  87. Shibata, Y., Sekiguchi, M., Ohtsuki, A. and Morita, M. (in press) Arsenic compounds in zoo- and phytoplanktons of marine origin. Appl. Organometal. Chem. Google Scholar
  88. Shiomi, K., Shinagawa, A., Igarashi, T. et al. (1984) Contents and chemical forms of arsenic in shellfishes in connection with their feeding habits, Bull. Jap. Soc. Sci. Fish. 50, 293–297.CrossRefGoogle Scholar
  89. Shiomi, K., Kakehashi, Y., Yamanaka, H. and Kikuchi, T. (1987) Identification of arsenobetaine and a tetramethylarsonium salt in the clam Meretrix lusoria. Appl. Organometal Chem. 1, 177–183.CrossRefGoogle Scholar
  90. Shiomi, K., Sugiyama, Y., Shimakura, K. and Nagashima, Y. (1995) Arsenobetaine as the major arsenic compound in the muscle of two species of freshwater fish. Appl. Organometal. Chem. 9, 105–109.CrossRefGoogle Scholar
  91. Smales, A.A. and Pate, B.D. (1952) The determination of sub-microgram quantities of arsenic by radioactivation. II: The determination of arsenic in sea water. Analyst 11, 188–195.CrossRefGoogle Scholar
  92. Stoeppler, M. and Brandt, K. (1979) Comparative studies on trace metal levels in marine biota II. Trace metals in krill, krill products and fish from the Antarctic Scotia Sea. Zeitschrift für Lebensmitteluntersuchung und Forschung 169, 95–98.CrossRefGoogle Scholar
  93. Sugawara, K. and Kanamori, S. (1964) The spectrophotometric determination of trace amounts of arsenate and arsenite in natural waters with special reference to phosphate determination. Bull. Chem. Soc. Jap. 37, 1358–1363.CrossRefGoogle Scholar
  94. Tagawa, S. and Kojima, Y. (1976) Arsenic content and its seasonal variation in seaweed. J. Shimonoseki Univ. Fish. 25, 67–74.Google Scholar
  95. Vahter, M. (1994) Species differences in the metabolism of arsenic compounds. Appl. Organometal. Chem. 8, 175–182.CrossRefGoogle Scholar
  96. Vahter, M., Marafante, E., Lindgren, A. and Dencker, L. (1982) Tissue distribution and subcellular binding of arsenic in marmoset monkeys after injection of 74As-arsenite. Arch. Toxicol. 51, 65–11.CrossRefGoogle Scholar
  97. Vahter, M., Couch, R., Nermell, B. and Nilsson, R. (1995) Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133, 262–268.CrossRefGoogle Scholar
  98. Vogel, G., Woznicka, M., Gfeller, H. et al. (1990) 1(3),2-Diacylglyceryl-3(l)-O-2′-(hydroxymethyl)(N, N, N-trimethyl)-ß-alanine (DGTA): a novel betaine lipid from Ochromonas danica (Chrysophyceae). Chem. Phys. Lipids 52, 99–109.CrossRefGoogle Scholar
  99. Welch, A.D. and Landau, R.L. (1942) The arsenic analogue of choline as a component of lecithin in rats fed arsenocholine chloride. J. Biol. Chem. 581–588.Google Scholar
  100. Whyte, J.N.C. and Englar, J.R. (1983) Analysis of inorganic and organic-bound arsenic in marine brown algae. Bot. Mar. 26, 159–164.CrossRefGoogle Scholar
  101. Zingde, M.D., Singbai, S.Y.S. et al. (1976) Arsenic, copper, zinc and manganese in the marine flora and fauna of coastal and estaurine waters around Goa. Indian J. Mar. Sci. 5, 212–217.Google Scholar

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© Springer Science+Business Media Dordrecht 1998

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  • John S. Edmonds
  • Kevin A. Francesconi

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