The In Vivo Role of the Receptors for IL-3, GM-CSF, and IL-5 (βc and βIL3)

  • Ryuichi Nishinakamura
  • Stefan Burdach
  • Uta Dirksen
  • Richard Murray
Part of the Contemporary Immunology book series (CONTIM)


Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are cytokines that exhibit a number of similar biological activities when tested on hematopoietic cells in vitro. IL-3 stimulates the development of multiple hematopoietic lineages in colony assays. GM-CSF was originally defined as a factor that stimulates colony formation of granulocytes and macrophages and has subsequently been shown to share many of the properties of IL-3 stimulation (1). IL-5 was cloned as a B-cell stimulation factor (2), but additionally exhibited eosinophil stimulatory activity (3). IL-3 and GM-CSF also share the property of stimulating eosinophils in vitro. The genes for IL-3, GM-CSF, and IL-5 are tightly linked on chromosome 11 in the mouse, and on chromosome 5 in the human.


Mutant Mouse Alveolar Macrophage Surfactant Protein Mutant Animal Human Genetic Disease 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Ryuichi Nishinakamura
  • Stefan Burdach
  • Uta Dirksen
  • Richard Murray

There are no affiliations available

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