Abstract
In the 1970s Goss and Harris [12] developed a new method for mapping human chromosomes. This method was based on irradiating human cells, rescuing some of the irradiated cells by hybridization to rodent cells, and analyzing the hybrid cells for surviving fragments of a particular human chromosome. For various technical reasons, radiation hybrid mapping languished for nearly a decade and a half until revived by Cox et al. [10]. The current, more sophisticated and successful versions raise many fascinating statistical problems. We will first discuss the mathematically simpler case of haploid radiation hybrids. Once this case is thoroughly digested, we will turn to the mathematically subtler case of polyploid radiation hybrids.
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© 1997 Springer Science+Business Media New York
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Lange, K. (1997). Radiation Hybrid Mapping. In: Mathematical and Statistical Methods for Genetic Analysis. Statistics for Biology and Health. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-2739-5_11
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DOI: https://doi.org/10.1007/978-1-4757-2739-5_11
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