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Molecular and Biologic Factors in Aging: The Origins, Causes, and Prevention of Senescence

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Geriatric Medicine

Abstract

Chronologic and biologic aging begin at conception, although senescent changes, defined here as functional declines, are usually apparent only after sexual maturation.1 With time, physiologic decrements become increasingly more common and increasingly compromise health and survival. Particularly notable is a reduced capacity with age to adjust to a variety of everyday stresses, probably due to defects in basic homeostatic mechanisms.2 The rates of aging and the life span for any species are governed by two general features: a genetic component that imparts a species-specific capability to carry out basic biologic processes necessary for life and reproduction and environmental, and lifestyle components that are superimposed on the intrinsic genetic design and can influence the overall rates of aging and susceptibility to disease processes.3

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Authors
  1. George T. Baker III
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  2. George R. Martin
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Editor information

Editors and Affiliations

  1. The Henry L. Schwartz Department of Geriatrics and Adult Development, The Mount Sinai Medical Center, 10029-6574, New York, NY, USA

    Christine K. Cassel M.D. (Professor and Chairman) & Diane E. Meier M.D. (Associate Professor) (Professor and Chairman) &  (Associate Professor)

  2. Center for Study of Aging and Geriatric Research Education and Clinical Center, Duke University Medical Center, 27710, Durham, NC, USA

    Harvey J. Cohen M.D. (Director) (Director)

  3. University of Washington Medical Center, 98195, Seattle, WA, USA

    Eric B. Larson M.D., M.P.H. (Medical Director) (Medical Director)

  4. Gerontology Division, Harvard Medical School, Brigham and Women’s Hospital, 02115, Boston, MA, USA

    Neil M. Resnick M.D. (Chief) (Chief)

  5. Geriatric Research Education and Clinical Center, Sepulveda VA Medical Center, 91343, Sepulveda, CA, USA

    Laurence Z. Rubenstein M.D., M.P.H. (Director) (Director)

  6. Department of Medicine, University of Chicago, 60637, Chicago, IL, USA

    Leif B. Sorensen M.D. (Professor and Vice Chairman) (Professor and Vice Chairman)

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Baker, G.T., Martin, G.R. (1997). Molecular and Biologic Factors in Aging: The Origins, Causes, and Prevention of Senescence. In: Cassel, C.K., et al. Geriatric Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-2705-0_1

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