Session V

Future Directions and Implications of Research on Dietary Fat and Genetics
  • Diane F. Birt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 422)

Abstract

The discussion was opened by Dr. Diane Birt with a summary of results from an epidemiological study and an animal investigation which support the interaction of genetics and nutrition in cancer development. Sellers et al.1 assessed the influence of body fat distribution and family history of breast and ovarian cancer on the risk of postmenopausal breast cancer. Linkage studies of the breast cancer susceptibility gene BRCA-1 on-chromosome 17p demonstrate a high association with families with a dual history of premenopausal breast and ovarian cancer. However, breast cancer family history alone is only weakly associated with a specific genetic mutation. The results from Sellers et al.1 suggested that a waist to hip ratio of >0.906 was associated with a higher risk of breast cancer amongst women with a family history of breast and ovarian cancer (relative risk = 4.8) than in women with a family history of breast cancer alone (relative risk = 2.1) or than women with no family history of breast or ovarian cancer (relative risk = 1.1). Although there were few patients with a family history of both breast and ovarian cancer, these results supported a strong relationship between obesity, or as was emphasized during the discussion, body fat distribution and breast cancer in women with genetic predisposition.

Keywords

Breast Cancer Ovarian Cancer Postmenopausal Breast Cancer Public Education Campaign Future Research Endeavor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sellers TA, Gapstur SM, Potter JD, Kushi LH, Bostick RM, Folsom AR. Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer. Am J Epidemiol 1993; 138: 799–803.Google Scholar
  2. 2.
    Lu J, Jiang C, Fontaine S, Thompson HJ. ras may mediate mammary cancer promotion by high fat. Nutr Cancer 1995; 23: 283–290.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Diane F. Birt
    • 1
  1. 1.Eppley Institute for Research in CancerUniversity of Nebraska Medical CenterOmahaUSA

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