Dopamine Autoreceptor Pharmacology and Function

Recent Insights
  • John D. Elsworth
  • Robert H. Roth
Part of the The Receptors book series (REC)


The potential importance of local feedback mechanisms in regulating dopaminergic activity was first noted by Farnebo and Hamberger (1), who observed that dopamine (DA) agonists were effective in attenuating the stimulus-evoked release of [3H]DA from striatal slices by an interaction with presynaptic receptors. When it became appreciated that catecholamine neurons, in addition to possessing receptors on their nerve terminals, appear to have receptors distributed over other parts of the neuron, such as the soma, dendrites, and preterminal axons, the term presynaptic receptors became inappropriate as a description for all these receptors. Carlsson (2) suggested that autoreceptor was a more appropriate term to describe them, as the sensitivity of these catecholamine receptors to the neurons’ own transmitter seemed more significant than their location at the synapse.


Prefrontal Cortex Dopamine Receptor Nucleus Accumbens Ventral Tegmental Area Dopamine Release 
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© Springer Science+Business Media New York 1997

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  • John D. Elsworth
  • Robert H. Roth

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