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Signaling Pathways Modulated by Dopamine Receptors

  • Chapter
The Dopamine Receptors

Part of the book series: The Receptors ((REC))

Abstract

Knowledge of the intracellular signaling events altered by the binding of dopamine to its receptors is critical to the understanding of how dopamine and dopaminergic drugs elicit their actions. Activation of a signal transduction mechanism that can regulate ion channels and turn on second messenger systems is the first step toward a variety of responses in neurons, from immediate changes in neuron excitability to long-term modulatory processes. Dopamine is a neurotransmitter and, thus, affects the excitability of neurons, but it also regulates protein kinases and transcription factors through signal transduction cascades initiated by the receptors. The long-term adaptive responses resulting from dopamine receptor activation or blockade are undoubtedly important for the effects of psychotropic drugs (1). Characterization of the initial events triggered by activation of dopamine receptors at a molecular level can contribute to an understanding of how changes in ion channel actuation, protein phosphorylation, and the genetic programs of the cells can occur.

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  1. Rita M. Huff
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  1. Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR, USA

    Kim A. Neve

  2. Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Rachael L. Neve

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Huff, R.M. (1997). Signaling Pathways Modulated by Dopamine Receptors. In: Neve, K.A., Neve, R.L. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2635-0_6

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  • DOI: https://doi.org/10.1007/978-1-4757-2635-0_6

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