Molecular Drug Design and Dopamine Receptors

  • Richard B. Mailman
  • David E. Nichols
  • Alexander Tropsha
Part of the The Receptors book series (REC)


The purpose of this chapter is to discuss the approaches we and others have used for the rational design of novel ligands for dopamine receptors. It is impossible in one chapter to provide both a detailed review of the technologies used for molecular drug design and their application to dopamine receptor drug design. Our goal, therefore, is to communicate a summary of the general strategies that are used for molecular drug design, a summary of current issues in the field and their development, and some examples from our own research with dopamine receptors that highlight the application of such methods.


Dopamine Receptor Drug Design Receptor Binding Site Receptor Model Dopamine Receptor Agonist 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Richard B. Mailman
  • David E. Nichols
  • Alexander Tropsha

There are no affiliations available

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