Molecular Biology of Dopamine Receptors

  • Kim A. Neve
  • Rachael L. Neve
Part of the The Receptors book series (REC)


The molecular biological characterization of the dopamine receptors began with the cloning of the gene and cDNA for the hamster beta-2 adrenergic receptor in 1986 (1), followed closely by the isolation of cDNAs encoding the turkey erythrocyte beta-adrenergic receptor (2) and the porcine ml muscarinic receptor (3). The realization that G protein-coupled receptors form a family of proteins related by primary structure and predicted secondary structural features, a family big enough to include the light-activated receptor rhodopsin, opened up the possibility of exploiting this homology for the molecular cloning of additional members of the gene family. Indeed, all the dopamine receptors have been cloned because of their homology to other dopamine or monoamine receptors.


Receptor Gene Dopamine Receptor Adenylate Cyclase Cytoplasmic Loop Chimeric Receptor 
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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kim A. Neve
  • Rachael L. Neve

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