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Molecular Biology of Dopamine Receptors

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The Dopamine Receptors

Part of the book series: The Receptors ((REC))

Abstract

The molecular biological characterization of the dopamine receptors began with the cloning of the gene and cDNA for the hamster beta-2 adrenergic receptor in 1986 (1), followed closely by the isolation of cDNAs encoding the turkey erythrocyte beta-adrenergic receptor (2) and the porcine ml muscarinic receptor (3). The realization that G protein-coupled receptors form a family of proteins related by primary structure and predicted secondary structural features, a family big enough to include the light-activated receptor rhodopsin, opened up the possibility of exploiting this homology for the molecular cloning of additional members of the gene family. Indeed, all the dopamine receptors have been cloned because of their homology to other dopamine or monoamine receptors.

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  1. Kim A. Neve
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Editors and Affiliations

  1. Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR, USA

    Kim A. Neve

  2. Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Rachael L. Neve

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© 1997 Springer Science+Business Media New York

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Neve, K.A., Neve, R.L. (1997). Molecular Biology of Dopamine Receptors. In: Neve, K.A., Neve, R.L. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2635-0_2

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  • DOI: https://doi.org/10.1007/978-1-4757-2635-0_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2637-4

  • Online ISBN: 978-1-4757-2635-0

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