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Dopamine Receptors and Clinical Medicine

  • Chapter
The Dopamine Receptors

Part of the book series: The Receptors ((REC))

Abstract

Other chapters in this volume document the explosive recent advances in the genetic, neuroanatomical, and molecular pharmacological understanding of both the traditional and most prevalent D1* and D2L dopamine (DA) receptors and their recently discovered subtypes, D2S, D3, D4, and D5 (1–4). These advances promise to yield important contributions to clinical medicine. The localization of the genes for each of the identified DA receptors to specific regions of human chromosomes has stimulated many studies seeking evidence of genetic linkage in specific clinical conditions, particularly psychiatric and neurological disorders. There is also much progress in the development of DA receptor type-selective radioligands for application in postmortem neuropathological analyses and for positron emission tomography (PET) or single photon emission computed tomography (SPECT) of the brain for clinical applications. Finally, the discovery of the novel DA receptor types, and of apparently selective localization of types D3 and D4 to limbic or other nonextrapyramidal regions of forebrain, has stimulated a vigorous search for small-molecule ligands selective for these targets as potential psychotropic medicinal agents.

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  1. Ross J. Baldessarini
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  1. Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR, USA

    Kim A. Neve

  2. Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA, USA

    Rachael L. Neve

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Baldessarini, R.J. (1997). Dopamine Receptors and Clinical Medicine. In: Neve, K.A., Neve, R.L. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2635-0_15

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  • DOI: https://doi.org/10.1007/978-1-4757-2635-0_15

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