Biochemical Characterization of Dopamine Receptors

  • Philip Strange
Part of the The Receptors book series (REC)


Following the recognition of dopamine as a neurotransmitter in the brain, independent of its role as a precursor of noradrenaline, there has been great interest in the sites of action of dopamine, namely the receptors. This interest was fueled by studies on certain brain diseases such as Parkinson’s disease and schizophrenia, which showed that dopamine had a role either in the pathogenesis or drug treatment of the disease and that substances acting at the receptors might act as therapeutic agents (1). Dopamine receptors were, therefore, studied intensively using a number of techniques including electrophysiology, animal behavioral experiments, and biochemical studies. In 1976 Cools and van Rossum reviewed a large body of data on the actions of dopamine and concluded that there might be more than one receptor for dopamine in the brain (2). Their conclusions were based on anatomical, electrophysiological, and pharmacological data, and they proposed two receptors—one of which was insensitive to the butyrophenone, haloperidol.


Dopamine Receptor Adenylate Cyclase Guanine Nucleotide Agonist Binding Aspartic Acid Residue 
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© Springer Science+Business Media New York 1997

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  • Philip Strange

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