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Biochemical and Molecular Properties of GABAB Receptors

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The GABA Receptors

Part of the book series: The Receptors ((REC))

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Abstract

γ-Aminobutyric acid (GABA) is known as one of the major inhibitory neurotransmitters in the brain. GABA receptors are many, and are pharmacologically classified into two major subtypes, GABAA and GABAB. The GABAA receptor is well-characterized pharmacologically. Muscimol and bicuculline, which are, respectively, an agonist and an antagonist for the GABAA receptor, bind selectively to the GABAA. Various central acting drugs, such as benzodiazepines and barbiturates, also have binding sites within the GABAA receptor complex (Doble and Martin, 1992). In addition, the GABAA receptor consists of heterogeneous subunits, and functions as a Cl-channel (Burt and Kamatchi, 1991; see also Chapter 2 of this volume).

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Authors
  1. Kinya Kuriyama
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  2. Masaaki Hirouchi
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Editors and Affiliations

  1. Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical School, Kansas City, KS, USA

    S. J. Enna

  2. Department of Pharmacology, The Medical School Edgbaston, University of Birmingham, UK

    Norman G. Bowery

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Kuriyama, K., Hirouchi, M. (1997). Biochemical and Molecular Properties of GABAB Receptors. In: Enna, S.J., Bowery, N.G. (eds) The GABA Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2597-1_9

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  • DOI: https://doi.org/10.1007/978-1-4757-2597-1_9

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