Cellular and Biochemical Responses to GABAB Receptor Activation

  • Martin Cunningham
  • S. J. Enna
Part of the The Receptors book series (REC)


The GABAB receptor was first identified with the characterization of a bicuculline-insensitive, GABA-mediated inhibition of transmitter release from peripheral and central nervous system (CNS) tissue (Bowery and Hudson, 1979; Bowery et al., 1980). The identification of baclofen as the prototypical GABAB receptor agonist provided a plausible mechanism of action for an agent used clinically for some time. These discoveries led to the development of potent and selective GABAB receptor agonists and antagonists which have, in turn, been crucial in characterizing the molecular, biochemical, electrophysiological, and behavioral responses associated with the GABAB receptor system (Bowery, 1993; Froestl et al., 1995a,b).


Adenylate Cyclase Adenylyl Cyclase Phorbol Ester Pertussis Toxin GABAB Receptor 
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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Martin Cunningham
  • S. J. Enna

There are no affiliations available

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