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The Interaction of Intravenous Anesthetic Agents with Native and Recombinant GABAA Receptors

An Electrophysiological Study

  • Chapter
Book cover The GABA Receptors

Part of the book series: The Receptors ((REC))

Abstract

The γ-aminobutyric acid type-A (GABAA) receptor is a ligand-gated, anion-selective, ion channel that exists as a pentameric complex of structurally homologous subunits (Sieghart, 1995; Smith and Olsen, 1995). Four families of subunit, termed α, β, δ, and γ, whose members may co-assemble to create GABAA receptors with differential biophysical and pharmacological properties, are currently recognized (Burt and Kamatchi, 1991; Macdonald and Angelotti, 1993; Whiting et al., 1995). GABAA receptor isoforms mediate the majority of the inhibitory action of GABA within the central nervous system (CNS), the activation of postsynaptically located GABAA receptors resulting in an increase in membrane conductance, predominantly to chloride ions, which shunts the influence of excitatory neurotransmitters, such as glutamate (Mody et al., 1994).

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Authors
  1. Jeremy J. Lambert
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  2. Delia Belelli
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  3. Marco Pistis
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  4. Claire Hill-Venning
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  5. John A. Peters
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Editors and Affiliations

  1. Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical School, Kansas City, KS, USA

    S. J. Enna

  2. Department of Pharmacology, The Medical School Edgbaston, University of Birmingham, UK

    Norman G. Bowery

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Lambert, J.J., Belelli, D., Pistis, M., Hill-Venning, C., Peters, J.A. (1997). The Interaction of Intravenous Anesthetic Agents with Native and Recombinant GABAA Receptors. In: Enna, S.J., Bowery, N.G. (eds) The GABA Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2597-1_5

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  • DOI: https://doi.org/10.1007/978-1-4757-2597-1_5

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