GABAA Receptor Agonists, Partial Agonists, and Antagonists

  • Povl Krogsgaard-Larsen
  • Bente Frølund
  • Bjarke Ebert
Part of the The Receptors book series (REC)


The neutral amino acid, γ-aminobutyric acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery. Some of these latter functions may be under central GABA control; others are managed by local GABA neurons. A large percentage, perhaps the majority, of central neurons are under GABA control. The complex mechanisms underlying the GABA-mediated neurotransmission have been extensively studied, using a broad spectrum of electrophysiological, neurochemical, pharmacological, and in recent years, molecular biological techniques (Krnjevic, 1974; Curtis and Johnston, 1974; Olsen and Venter, 1986; Redburn and Schousboe, 1987; Bowery and Nistico, 1989; Bowery et al., 1990; Biggio and Costa, 1990; Schousboe et al., 1992a).


Gaba Receptor Cerebellar Granule Cell Cerebellar Granule Neuron Neuroactive Steroid Gaba Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Povl Krogsgaard-Larsen
  • Bente Frølund
  • Bjarke Ebert

There are no affiliations available

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