Structure and Function of GABA Reuptake Systems

  • Baruch I. Kanner
Part of the The Receptors book series (REC)


High affinity sodium-coupled transport systems are responsible for the reuptake of neurotransmitters from the synaptic cleft. They appear to play an important role in the overall process of synaptic transmission, namely in its termination (Iversen, 1971, 1973). The process is catalyzed by sodium-coupled neurotransmitter transport systems located in plasma membranes of nerve endings and glial cells (Kanner, 1983, 1989; Kanner and Schuldiner, 1987). These transport systems have been investigated in detail by using plasma membranes obtained upon osmotic shock of synaptosomes. It appears that these transporters are coupled not only to sodium, but also to additional ions like potassium or chloride.


Dopamine Transporter Plasma Membrane Vesicle Gaba Transporter Neurotransmitter Transporter Glycine Transporter 
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© Springer Science+Business Media New York 1997

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  • Baruch I. Kanner

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