Nongenomic Actions of Thyroid Hormone

  • Paul J. Davis
  • Faith B. Davis
Part of the Contemporary Endocrinology book series (COE, volume 2)


Nonnuclear or nongenomic cellular actions of thyroid hormone are those that are independent of traditional nuclear thyroid hormone receptors (TRs) (1,2). The scope of these actions is broad (Fig. 1), at least in part because they involve various organelles, specialized functions of the plasma membrane, and biochemical events in cytoplasm. Recognition of the existence of nongenomic actions over the past 15 yr has provided a complex picture of the roles of thyroid hormone in the cell beyond its important functions in regulating gene expression (3,4).


Thyroid Hormone ATPase Activity Thyroid Hormone Action Nongenomic Action Nongenomic Effect 
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© Springer Science+Business Media New York 1997

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  • Paul J. Davis
  • Faith B. Davis

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