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Resistance to Thyroid Hormone

  • Chapter
Diseases of the Thyroid

Part of the book series: Contemporary Endocrinology ((COE,volume 2))

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Abstract

The concept of a hormone-resistant disease has been introduced around the 1940s by Fuller Albright by studying the rickets resistant to Vitamin D therapy and the “Pseudohypoparathyroidism—an example of Seabright-Bantam syndrome” (1,2).He called the disease “pseudo,” as the patients showed clinical features of hypoparathyroidism, but the injection of parathyroid hormone was not followed by the expected increases of serum calcium levels and urinary phosphate excretion. Thus, the term “pseudo” entered into the medical vocabulary to indicate an endocrine disorder resembling a known disease, but accompanied by failure of the end-organ to respond to the specific hormone. Several examples of insensitivity to many hormones, including insulin, corticosteroids, androgens, estrogens, anterior and posterior pituitary hormones, have been reported in the last 50 yr. Moreover, it is now clearly demonstrated that genetic mutations of hormone receptor proteins or proteins involved in the signal transduction are the underlying cause of most clinical conditions that we prefer today to call not “pseudo,” but “resistance to thyroid hormone action.”

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Authors
  1. Paolo Beck-Peccoz MD
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  2. Carmela Asteria MD
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  3. Deborah Mannavola MD
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  1. Division of Endocrinology and Metabolism, University of Massachusetts Medical Center, Worcester, Massachusetts, USA

    Lewis E. Braverman MD

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Beck-Peccoz, P., Asteria, C., Mannavola, D. (1997). Resistance to Thyroid Hormone. In: Braverman, L.E. (eds) Diseases of the Thyroid. Contemporary Endocrinology, vol 2. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2594-0_11

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  • DOI: https://doi.org/10.1007/978-1-4757-2594-0_11

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