Diagnosis and Treatment of Allergic Diseases of the Eye

  • Kari Blaho
  • Stephen Winbery
Part of the Current Clinical Practice book series (CCP)


Allergens and other ocular irritants can be deposited directly onto the surface of the eye from the surrounding environment, deposited on hair and skin, or rubbed, wiped, or washed into the eye. There is a net flow with gravity of sebum and trapped particles from the hair that can easily enter the eye. Substances can also gain access to ocular tissue via the systemic circulation. Many agents can be concentrated and secreted in tears, causing allergic or irritative conjunctivitis. Finally, compounds have a more difficult route of entry into the posterior structures of the eye. The cornea and the lens serve as an effective barrier for most agents that are administered topically, and there is a blood-retinal barrier, analogous to the blood-brain barrier, that protects the eye from the systemic circulation. Molecules cross this barrier based on size, charge, and lipid solubility.


Allergic Disease Ocular Surface Allergic Conjunctivitis Conjunctival Injection Ocular Allergy 
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Suggested Reading

  1. Facts and Comparisons Division, J. B. Lippincott Company, St. Louis 1995.Google Scholar
  2. Jaanus SD, Hegeman SL, Swanson, MW. Antiallergy Drugs and Decongestants In Clinical Ocular Pharmacology Bartlett JD, Jaanus SD (ed). Boston: Butterworth-Heinemann, 1995.Google Scholar
  3. Jennings B. Primary Care of Ocular Allergy, JAOA 61: 1990.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kari Blaho
  • Stephen Winbery

There are no affiliations available

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