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Molecular Diagnostics pp 317–339Cite as

Molecular Genetics and the Diagnosis of Hematological Malignancies

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Part of the book series: Pathology and Laboratory Medicine ((PLM))

Abstract

The hematological malignancies can be broadly categorized into the malignant lymphomas, which include the two major categories, non-Hodgkin’ s lymphoma (NHL) and Hodgkin’ s disease, the acute and chronic lymphoid leukemias, which may be of B- or T-cell type, acute myelogenous leukemia, the myelodysplastic syndromes, and the myeloproliferative disorders. The goal of this chapter is to focus on the hematopathological approach to the diagnosis of the various hematological disorders with emphasis on those disorders in which molecular genetic methods, specifically Southern blotting and polymerase chain reaction (PCR), are most commonly employed.

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Authors
  1. William N. Rezuke
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  2. Evelyn C. Abernathy
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    William B. Coleman

  2. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Gregory J. Tsongalis

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© 1997 Springer Science+Business Media New York

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Rezuke, W.N., Abernathy, E.C. (1997). Molecular Genetics and the Diagnosis of Hematological Malignancies. In: Coleman, W.B., Tsongalis, G.J. (eds) Molecular Diagnostics. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2588-9_15

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  • DOI: https://doi.org/10.1007/978-1-4757-2588-9_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-2590-2

  • Online ISBN: 978-1-4757-2588-9

  • eBook Packages: Springer Book Archive

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