Herpes Simplex Virus Vectors for Gene Therapy of the Nervous System

  • Angela P. Dyer
  • Frank Tufaro


The basic idea of gene transfer arose in the late 1950s, after the discovery that viruses have an intrinsic capability to transfer their genetic material into infected cells. By this mechanism, some viruses, such as retroviruses, are able to establish life-long expression of a foreign gene in cells of diverse origins. Unfortunately, it is not possible to infect nondividing cells with retroviruses. This has led to the development of nontoxic mutants of other viruses, such as adenovirus and herpesvirus, to infect other cell types, such as neurons, which are refractory to infection by retroviruses.


Virus Stock Tissue Culture Dish Helper Virus Latex Glove Rubber Policeman 
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Further Reading

  1. Friedmann, T. (1994), Gene therapy for neurological disorders. Trends Genet, 10, 210–214.PubMedCrossRefGoogle Scholar
  2. Glorioso, J. C., DeLuca, N. A., and Fink, D. J. (1995), Development and application of herpes simplex virus vectors for human gene therapy. Annu. Rev. Microbiol. 49, 675–710.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Angela P. Dyer
  • Frank Tufaro

There are no affiliations available

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