Effects of Aging on the Hormonal Response to Stress

  • Gary A. Wittert
  • John E. Morley
Part of the Contemporary Endocrinology book series (COE, volume 4)


During aging, a progressive decline in the ability of an organism to maintain homeostasis occurs. The mechanism by which senescence of the endocrine system occurs is not known, but presumably involves both genetic and environmental components. In the hypothalamus, morphological changes occur in association with the aging process. In the rat, neurons are lost from areas that regulate temperature and gonadotropin secretion (1). In humans, there is marked enlargement of neurons in the supraoptic and paraventricular nuclei, but no loss of neurons from these areas (2). Parvicellular corticotropin-releasing hormone- (CRH), containing neurons in the paraventricular nucleus have been observed to be activated during the course of aging (3). However, with aging the number of neurons in the suprachiasmatic nucleus decreases (3).


GROWTII Hormone Luteinizing Hormone Prolactin Level GROWTII Hormone Response Luteinizing Hormone Level 
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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Gary A. Wittert
  • John E. Morley

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