The Seizing Brain
Epilepsy (from the Greek epilambanein, to surprise) is a widely diffused neurological disorder that affects the lives of about 1% of the Western population. Although a classification of the different kinds of epilepsy goes beyond the scope of this chapter, it is necessary to underline that what is actually called status epilepticus consists in a series of tonic-clonic seizures with no complete recovery in between. The neuronal activation and subsequent damage during serial seizures have been investigated for several years now, elucidating many of the mechanisms that follow cell overstimulation. Few attempts, however, have been made to connect the different areas in which scientists carry out their studies: Physiology and biochemistry, for instance, have seldom been merged in a single investigation. This chapter describes one such study, in which physiological parameters have been correlated to biochemical events in an animal model of status epilepticus.
KeywordsStatus Epilepticus Phosphatidic Acid Free Fatty Acid Level Recurrent Seizure Lipid Metabolite
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