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Bone Cement, Part 2

Biomaterials to Restore Function in People with Physical Disabilities

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Human Biomaterials Applications

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Abstract

In the repair of structural tissue, such as bone, the bridging of gaps between tissue boundaries and the spatial resolution of defect sites are frequent challenges. In the repair of bone, bone ends must be stabilized and bone stability must be maintained during healing. The goals in repair of bone tissue are complete restoration of function and aesthetic acceptability. Two lines of current orthopedic research address these problems. The first deals with biomaterials development where biodegradable bone cements are sought to replace excised bone fragments and, with erosion rates commensurate with growth of new bone, serve as osteoconductive pathways for healing. The second deals with utilization of bone repair proteins (BRPs) where bone growth is actively promoted and the BRPs function as osteoinductive materials. The former addresses bone stabilization, the latter the duration of the healing processes. Although bone morphogen(et)ic protein (BMP) and osteogenic protein (OP) are more commonly used terms in reference to the bone repair proteins, these terms and their initials are increasingly associated with particular company products. We will use BRP to discuss the more general field of repair proteins, and reserve “BMP” or “OP” for specific product references.

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Authors
  1. Donald L. Wise
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  2. Debra J. Trantolo
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  3. Hisanori Nagaoka
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  4. Joseph D. Gresser
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  5. David E. Altobelli
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  6. Michael J. Yaszemski
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  7. Gary E. Wnek
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Editor information

Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Belmont, MA, USA

    Debra J. Trantolo PhD  & Joseph D. Gresser PhD  & 

  3. Harvard School of Dental Medicine, Boston, MA, USA

    David E. Altobelli DMD, MD

  4. USAF Medical Center, Lackland AFB, TX, USA

    Michael J. Yaszemski MD, PhD

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© 1996 Springer Science+Business Media New York

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Wise, D.L. et al. (1996). Bone Cement, Part 2. In: Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., Gresser, J.D. (eds) Human Biomaterials Applications. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2487-5_9

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  • DOI: https://doi.org/10.1007/978-1-4757-2487-5_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-012-0

  • Online ISBN: 978-1-4757-2487-5

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