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Bone-Inducing Factors in Osteoinductive Implants

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Human Biomaterials Applications

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Abstract

Over the last decade, considerable attention has been focused on the cellular and molecular aspects of bone cell biology. In spite of advances in this area and in biomaterials science, autogeneic bone grafting still is considered to be the most effective method for augmenting bone regeneration following orthopedic surgery. The biologic potential of autogeneic cancellous bone graft material may be attributed to resident osteogenic cells that survive, proliferate, and ultimately produce new bone at the transplanted site (1,2).However, the disadvantages of autogenous bone grafting include the fact that:

  1. 1.

    A second operation is required to obtain the graft, resulting in functional and cosmetic defects as well as pain at the donor site;

  2. 2.

    The supply of autogenous bone for grafting is limited; and

  3. 3.

    Cancellous bone with high osteogenic potential does not confer significant mechanical strength to the donor site.

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Authors
  1. Kunio Takaoka
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  2. Hideki Yoshikawa
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  3. Shimpei Miyamoto
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  4. Jun Hashimoto
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  5. Masashi Matsui
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  6. Keiro Ono
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Editor information

Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Belmont, MA, USA

    Debra J. Trantolo PhD  & Joseph D. Gresser PhD  & 

  3. Harvard School of Dental Medicine, Boston, MA, USA

    David E. Altobelli DMD, MD

  4. USAF Medical Center, Lackland AFB, TX, USA

    Michael J. Yaszemski MD, PhD

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© 1996 Springer Science+Business Media New York

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Takaoka, K., Yoshikawa, H., Miyamoto, S., Hashimoto, J., Matsui, M., Ono, K. (1996). Bone-Inducing Factors in Osteoinductive Implants. In: Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., Gresser, J.D. (eds) Human Biomaterials Applications. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2487-5_4

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  • DOI: https://doi.org/10.1007/978-1-4757-2487-5_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-012-0

  • Online ISBN: 978-1-4757-2487-5

  • eBook Packages: Springer Book Archive

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