Tissue Regeneration by Use of Analogs of Extracellular Matrix

  • Diane L. Ellis
  • Ioannis V. Yannas


On injury to the extracellular matrix (ECM), the cells of the inflammatory response remove the damaged tissue components by a combination of intracellular and extracellular degradation. The inflammatory response involves the migration of cells into the wound site to participate in healing processes, such as clotting, phagocytosis, neovascularization, and new collagen synthesis. The goal of the wound healing process is to replace the dead tissue with living tissue by two basic mechanisms, repair or regeneration. Repair involves the replacement of the dead tissue by granulation tissue, a transitional tissue that is able to retract the wound space. Repair is necessary when tissue containing permanent cells is damaged. During the repair process, the edges of the wound are progressively brought together by the retraction of granulation tissue. This wound contraction occurs by the action ofmyofibroblasts. The end result of this repair process is the formation of scar tissue. Wound contraction is of great importance in reducing the size of the wound so that the body can maintain homeostasis and resist infection by microorganisms. However, contraction may result in disfigurement, excessive scarring, and impaired function of the affected organs (1). Regeneration, on the other hand, replaces the lost cells and tissues with cells and tissues with similar functional and morphological characteristics. Repair is necessary when tissue containing permanent cells is damaged. Regeneration is possible when injury occurs in tissues composed of labile or stable cells. Regeneration is the preferable outcome to injury.


Average Pore Diameter Silicone Tube Bullous Pemphigoid Wound Contraction Peripheral Nerve Regeneration 
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  1. 1.
    Peacock EE Jr and Van Winkle W. Surgery and Biology of Wound Repair 1970; Saunders, Philadelphia.Google Scholar
  2. 2.
    Wallace H. Vertebrate Limb Regeneration 1981; Wiley, New York.Google Scholar
  3. 3.
    Roels H. Tissue Repair and Regeneration 1981; Elsevier, Amsterdam, p 243.Google Scholar
  4. 4.
    Peacock EE Jr. Principles ofSurgery,4th ed, 1984; McGraw-Hill, New York, p 289.Google Scholar
  5. 5.
    Billingham RE and Medawar PB. JExp Bio11951; 28: 385.Google Scholar
  6. 6.
    Billingham RE and Medawar PB. J Anat 1955; 89: 114.Google Scholar
  7. 7.
    Lundborg G, Dahlin LB, Danielsen N, Gelberman RH, Longo FM, Powell HL, et al. Exp Neurol 1982; 76: 361.CrossRefGoogle Scholar
  8. 8.
    Lundborg G. Acta Orthop Scand 1987; 58: 145.CrossRefGoogle Scholar
  9. 9.
    Krejci NC and McGuire J. JDermatol Sci 1992; 4 (3): 149.CrossRefGoogle Scholar
  10. 10.
    Nanchahal J and Ward CM. BrJPlast Surg 1992; 45 (5): 354.Google Scholar
  11. 11.
    Phillips TJ. JDermatol Surg Oncol 1993; 19(8): 794.Google Scholar
  12. 12.
    Cairns B, deSerres S, Peterson HD, and Meyer AA. Arch Surg 1993; 128: 1246.CrossRefGoogle Scholar
  13. 13.
    Landstrom A and Yannas IV. Encyclopedia of Neuroscience,1996; in press.Google Scholar
  14. 14.
    Yannas IV. Collagen: Vol. III, Biotechnology 1988; ch 4. CRC, Boca Raton, FL.Google Scholar
  15. 15.
    Yannas IV. Angewandte Chemie 1990; 29: 20.CrossRefGoogle Scholar
  16. 16.
    Yannas IV. Materials Science and Technology, A Comprehensive Treatment 1992; vol 14, ch 5.Google Scholar
  17. 17.
    Yannas IV and Burke JF. JBiomed Mat Res 1980; 14: 65.CrossRefGoogle Scholar
  18. 18.
    Yannas IV, Burke JF, Orgill DP, and Skrabut EM. Science 1982; 215: 174.CrossRefGoogle Scholar
  19. 19.
    Yannas IV, Lee E, Skrabut EM, Orgill DP, and Murphy GF. J Cell Biol 1987; 105: 223a.Google Scholar
  20. 20.
    Medawar PB. Nature (Lond) 1941; 148: 783.CrossRefGoogle Scholar
  21. 21.
    Billingham RE and Reynolds J. Brit J Plast Surg 1953; 5: 25.Google Scholar
  22. 22.
    Delescluse C, Regnier M, Opatowski L, and Prunieras M. Acta Derm Venereol 1977; 57: 469.Google Scholar
  23. 23.
    Prunieras M, Delecluse C, and Regnier M. Phar Ther 1980; 9: 271.CrossRefGoogle Scholar
  24. 24.
    Prunieras M, Delecluse C, and Regnier M. Jlnvest Dermatol 1976; 67: 58.CrossRefGoogle Scholar
  25. 25.
    Saurat JH, Didierjean L, Pavolvitch JH, Laouar D, and Balsan S. Jlnvest Dermatol 1981; 76: 221.CrossRefGoogle Scholar
  26. 26.
    Regnier M, Delescluse C, and Prunieras M. Acta Derm Venereol 1973; 53: 241.Google Scholar
  27. 27.
    Yannas IV. The Surgical Wound 1981; ch 15. Lea & Febiger, Philadelphia.Google Scholar
  28. 28.
    Burke JF, Yannas IV, Quinby WC Jr, Bondoc CC, and Jung WK. Ann Surg 1981; 194: 413.CrossRefGoogle Scholar
  29. 29.
    Yannas IV, Orgill DP, Silver J, Norregaard T, Zervas NT, and Schoene WC. Trans Soc Biomat 1985; 8: 146.Google Scholar
  30. 30.
    Huang C. DSc dissertation 1974; Massachusetts Institute of Technology, Cambridge, MA.Google Scholar
  31. 31.
    Yannas IV, Burke JF, Huang C, and Gordon PL. Polym PreprAm Chem SocDivPolym Chem 1975; 16 (2): 209.Google Scholar
  32. 32.
    Piez KA. Encyclopedia of Polymer Science and Engineering,1985; vol. 3, Wiley, New York.Google Scholar
  33. 33.
    Trelstad RL. The Role of Extracellular Matrix in Development 1984; Liss, New York.Google Scholar
  34. 34.
    Nimni ME and Harkness RD. Collagen, vol. 1, Biochemistry 1988; CRC, Boca Raton, FL.Google Scholar
  35. 35.
    Yannas IV, Burke JF, Gordon PL, Huang C, and Rubinstein RH. JBiomed Mat Res 1980; 14: 107.CrossRefGoogle Scholar
  36. 36.
    Yannas IV. Rev Macromol Chem 1972; C7: 49.CrossRefGoogle Scholar
  37. 37.
    Mathews MB. Connec Tis 1975; Springer, New York.CrossRefGoogle Scholar
  38. 38.
    Dagalakis N, Flink J, Stasikelis P, Burke JF, and Yannas IV. JBiomed Mater Res 1980; 14: 511.CrossRefGoogle Scholar
  39. 39.
    Bowes JH and Taylor JE. JAm Leather Chem Assoc 1971; 66: 96.Google Scholar
  40. 40.
    Sung NH. PhD dissertation 1972; Massachusetts Institute of Technology, Cambridge, MA.Google Scholar
  41. 41.
    Cheung DT and Nimni ME. Conn Tissue Res 1982; 10: 201.CrossRefGoogle Scholar
  42. 42.
    Yannas IV, Lee E, Orgill DP, Skrabut EM, and Murphy GF. Proc Natl Acad Sci USA 1989; 86: 933.CrossRefGoogle Scholar
  43. 43.
    Gordon PL, Huang C, Lord RC, and Yannas IV. Macromolecules 1974; 7: 954.CrossRefGoogle Scholar
  44. 44.
    Hall CE, Jarkus MA, and Schmitt FO. JAm Chem Soc 1942; 64: 1234.CrossRefGoogle Scholar
  45. 45.
    Wolpers C. Klin Wschr 1943; 22: 624.CrossRefGoogle Scholar
  46. 46.
    Highberger JH, Gross J, and Schmitt FO. J Am Chem Soc 1950; 72: 3321.CrossRefGoogle Scholar
  47. 47.
    HighbergerJH, Gross J, and Schmitt FO. Proc Natl Acad Sci USA 1951; 37: 286.CrossRefGoogle Scholar
  48. 48.
    Forbes MJ. MS dissertation 1980; Massachusetts Institute of Technology, Cambridge, MA.Google Scholar
  49. 49.
    Sylvester M, Yannas IV, Salzman EW, and Forbes MJ. Thromb Res 1989; 55: 135.CrossRefGoogle Scholar
  50. 50.
    Yannas IV, Burke JF, Huang C, and Gordon PL. J Biomed Mater Res 1975; 9: 623.CrossRefGoogle Scholar
  51. 51.
    Mandl I, Maclennan JD, and Howes EL. J Clin Invest 1953; 32: 1323.CrossRefGoogle Scholar
  52. 52.
    Yannas IV. Encyclopedia of Polymer Science and Engineering,1989; 2nd ed, vol 15. Wiley, New York.Google Scholar
  53. 53.
    Suematsu N. Microsurgery 1989; 10 (1): 71.CrossRefGoogle Scholar
  54. 54.
    Yannas IV, Orgill DP, Skrabut EM, and Burke JF. Polymeric Materials and Artilcal Organs 1984; ch 13. American Chemical Society, Washington DC.Google Scholar
  55. 55.
    Murphy GF, Orgill DP, Hancock WW, Fonferko EB, and Yannas IV. Lab Invest 1986; 54: 45A.Google Scholar
  56. 56.
    Ferdman AG and Yannas IV. Trans Soc Biomat 1987; 10: 207.Google Scholar
  57. 57.
    Ferdman AG and Yannas IV. J Invest Dermatol 1993; 100, 710.CrossRefGoogle Scholar
  58. 58.
    Demling RH. NEngl JMed 1985; 313: 1389.CrossRefGoogle Scholar
  59. 59.
    Heimbach D, Luterman A, Burke J, Cram A, Herndon D, Hunt J, et al. Anna! Surg 1988; 208: 313.CrossRefGoogle Scholar
  60. 60.
    Michaeli D and McPherson M. JBurn Care Rehabil 1990; 11: 21.CrossRefGoogle Scholar
  61. 61.
    Stem R, McPherson M, and Longaker MT. JBurn Care Rehabil 1990; 11: 7.CrossRefGoogle Scholar
  62. 62.
    Yannas IV, Krarup C, Chang A, Norregaard TV, Zervas NT, and Sethi R. Soc Neurosci Abs 1987; 13: 1043.Google Scholar
  63. 63.
    Chang AS and Yannas IV. Encyclopedia ofNeuroscience,suppl. 2; 1992 (Smith B and Adelman G, eds.), Birkhaüser, Boston, pp. 125, 126.Google Scholar
  64. 64.
    Chang AS, Yannas IV, Perutz S, Loree H, Sethi RR, Krarup C, et al. Progress in Biomedical Polymers 1990; Plenum, New York.Google Scholar
  65. 65.
    Yannas IV, Chang AS, Perutz S, Krarup C, Norregaard TV, and Zervas NT. Biotechnology and Polymers 1991; Plenum, New York.Google Scholar

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© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Diane L. Ellis
  • Ioannis V. Yannas

There are no affiliations available

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